Tomentin

CAS# 28449-62-9

Tomentin

Catalog No. BCN5180----Order now to get a substantial discount!

Product Name & Size Price Stock
Tomentin: 5mg $615 In Stock
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Quality Control of Tomentin

Number of papers citing our products

Chemical structure

Tomentin

3D structure

Chemical Properties of Tomentin

Cas No. 28449-62-9 SDF Download SDF
PubChem ID 14059525 Appearance White powder
Formula C11H10O5 M.Wt 222.2
Type of Compound Coumarins Storage Desiccate at -20°C
Synonyms 5-Hydroxy 6,7-dimethoxycoumarin
Solubility Soluble in DMSO
Chemical Name 5-hydroxy-6,7-dimethoxychromen-2-one
SMILES COC1=C(C(=C2C=CC(=O)OC2=C1)O)OC
Standard InChIKey KCPNDUHAXDHRKX-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)10(13)11(8)15-2/h3-5,13H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tomentin

The barks of Jatropha curcas

Biological Activity of Tomentin

Description1. Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%.
TargetsImmunology & Inflammation related

Tomentin Dilution Calculator

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Tomentin Molarity Calculator

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Preparing Stock Solutions of Tomentin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5005 mL 22.5023 mL 45.0045 mL 90.009 mL 112.5113 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL 18.0018 mL 22.5023 mL
10 mM 0.45 mL 2.2502 mL 4.5005 mL 9.0009 mL 11.2511 mL
50 mM 0.09 mL 0.45 mL 0.9001 mL 1.8002 mL 2.2502 mL
100 mM 0.045 mL 0.225 mL 0.45 mL 0.9001 mL 1.1251 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tomentin

Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia.[Pubmed:24488717]

Planta Med. 2014 Feb;80(2-3):209-14.

Sphaeralcea angustifolia, an endangered plant species in Mexico, is employed to treat inflammatory processes and as a wound healing remedy. Scopoletin (1) was reported as one of the main bioactive compounds in this plant. Here, we isolated and identified compounds with anti-inflammatory properties from the suspension-cultured cells of S. angustifolia. The CH2Cl2 : CH3OH extract of the cells exhibited anti-inflammatory properties in acute inflammation models. Two compounds were isolated, 5-hydroxy-6,7-dimethoxycoumarin, named Tomentin (2), and 2-(1,8-dihydroxy-4-isopropyl-6-methyl-7-methoxy)-naphthoic acid, denominated as sphaeralcic acid (3). Their structures were determined by spectroscopic and spectrometric analyses. The anti-inflammatory effects of both compounds were also evaluated. At a dose of 45 mg/kg, compound 2 inhibited the formation of lambda-carrageenan footpad edema at 58 %, and compound 3 at 66 %. Local application of compound 2 (225 mM per ear) or 3 (174 mM per ear) inhibited the phorbol ester-induced auricular edema formation by 57 % or 86 %, respectively. The effect of compound 3 was dose-dependent and the ED50 was 93 mM.

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