Uralsaponin D

CAS# 1262489-44-0

Uralsaponin D

Catalog No. BCN7895----Order now to get a substantial discount!

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Quality Control of Uralsaponin D

Number of papers citing our products

Chemical structure

Uralsaponin D

3D structure

Chemical Properties of Uralsaponin D

Cas No. 1262489-44-0 SDF Download SDF
PubChem ID 102051868 Appearance Powder
Formula C42H58O18 M.Wt 850.90
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC8(CC7OC8=O)C(=O)O)C)C)C)C
Standard InChIKey JHJRJJRSKZLTFQ-AEZYHTSRSA-N
Standard InChI InChI=1S/C42H58O18/c1-37(2)19-7-10-41(6)30(18(43)13-16-17-14-42(35(53)54)15-21(57-36(42)55)38(17,3)11-12-40(16,41)5)39(19,4)9-8-20(37)56-34-29(25(47)24(46)28(59-34)32(51)52)60-33-26(48)22(44)23(45)27(58-33)31(49)50/h13,17,19-30,33-34,44-48H,7-12,14-15H2,1-6H3,(H,49,50)(H,51,52)(H,53,54)/t17-,19-,20-,21+,22-,23-,24-,25-,26+,27-,28-,29+,30+,33-,34+,38+,39-,40+,41+,42+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Uralsaponin D

The roots of Glycyrrhiza uralensis

Biological Activity of Uralsaponin D

Description1. Uralsaponin D displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 μmol/L, it could significantly increase the cytotoxic activity after hydrolysis.

Uralsaponin D Dilution Calculator

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Uralsaponin D Molarity Calculator

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Preparing Stock Solutions of Uralsaponin D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1752 mL 5.8761 mL 11.7523 mL 23.5045 mL 29.3807 mL
5 mM 0.235 mL 1.1752 mL 2.3505 mL 4.7009 mL 5.8761 mL
10 mM 0.1175 mL 0.5876 mL 1.1752 mL 2.3505 mL 2.9381 mL
50 mM 0.0235 mL 0.1175 mL 0.235 mL 0.4701 mL 0.5876 mL
100 mM 0.0118 mL 0.0588 mL 0.1175 mL 0.235 mL 0.2938 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Uralsaponin D

Chemical constituents of triterpenoid saponins from Glycyrrhiza uralensis.

Chinese Traditional & Herbal Drugs, 2013, 44(12):1552-1557.

To study the chemical constituents from the roots and rhizomes of Glycyrrhiza uralensis. Methods: The compounds were separated and purified by solvent and chromatographic methods. Their structures were identified by spectroscopic techniques. Results: Fourteen triterpenoid saponins isolated from 50% ethanol extract of the roots and rhizomes of G. uralensis were identified as uralsaponin C (1), Uralsaponin D (2), licorice-saponin A3 (3), uralsaponin F (4), 22β-acetoxyl-glycyrrizin (5), 24-hydroxyl-licorice-saponin E2 (6), licorice-saponin E2 (7), licorice-saponin G2 (8), 22β-acetoxyl-glyrrhaldehyde (9), 3β-O-[β-D-glucuronopyranosyl-(1→2) - β-D-glucuronopyranosyl]-glycyrretol (10), araboglycyrrhizin (11), licorice-saponin J2 (12), glycyrrhizin (13), and glycyrrhetic acid monoglucuronide (14). Compounds 1-14 showed the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μmol/L. The aglycones of compounds 2, 6-8, and 13 displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 μmol/L. Conclusion: Compound 14 is a new natural product, and compound 11 is isolated from the plant for the first time; Compounds 1-14 show no cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721, and the aglycones of compounds 2, 6-8, and 13 could significantly increase the cytotoxic activity after hydrolysis.

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