VAL-083

Bi-functional alkylating agent CAS# 23261-20-3

VAL-083

Catalog No. BCC2024----Order now to get a substantial discount!

Product Name & Size Price Stock
VAL-083: 5mg $299 In Stock
VAL-083: 10mg Please Inquire In Stock
VAL-083: 20mg Please Inquire Please Inquire
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Quality Control of VAL-083

Number of papers citing our products

Chemical structure

VAL-083

3D structure

Chemical Properties of VAL-083

Cas No. 23261-20-3 SDF Download SDF
PubChem ID 31789 Appearance Powder
Formula C6H10O4 M.Wt 146.14
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Dianhydrodulcitol; Dianhydrogalactitol
Solubility DMF : ≥ 100 mg/mL (684.28 mM)
H2O : 50 mg/mL (342.14 mM; Need ultrasonic)
*"≥" means soluble, but saturation unknown.
Chemical Name 1,2-bis(oxiran-2-yl)ethane-1,2-diol
SMILES C1C(O1)C(C(C2CO2)O)O
Standard InChIKey AAFJXZWCNVJTMK-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of VAL-083

DescriptionVAL-083 is a structurally unique first-in-class N7-bifunctional alkylating agent of DNA.
TargetsDNA    

VAL-083 Dilution Calculator

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VAL-083 Molarity Calculator

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Preparing Stock Solutions of VAL-083

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.8428 mL 34.2138 mL 68.4275 mL 136.8551 mL 171.0688 mL
5 mM 1.3686 mL 6.8428 mL 13.6855 mL 27.371 mL 34.2138 mL
10 mM 0.6843 mL 3.4214 mL 6.8428 mL 13.6855 mL 17.1069 mL
50 mM 0.1369 mL 0.6843 mL 1.3686 mL 2.7371 mL 3.4214 mL
100 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.3686 mL 1.7107 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on VAL-083

VAL-083 is a bi-functional alkylating agent, with potential antitumor activity.

VAL-083 can cross the blood brain barrier and appears to be selective for tumor cells. VAL-083 alkylates and crosslinks DNA which ultimately inhibit the proliferation of cancer cells. VAL-083 does not show cross-resistance to other conventional chemotherapeutic agents. The half-life of VAL-083 in the brain is long. VAL-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.

Reference:
http://www. delmarpharma.com/product_development_programs/val083/

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Description

VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.

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