Y-320

immunomodulator CAS# 288250-47-5

Y-320

Catalog No. BCC5202----Order now to get a substantial discount!

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Y-320: 5mg $92 In Stock
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Quality Control of Y-320

Number of papers citing our products

Chemical structure

Y-320

3D structure

Chemical Properties of Y-320

Cas No. 288250-47-5 SDF Download SDF
PubChem ID 22227931 Appearance Powder
Formula C27H29ClN6O2 M.Wt 505.01
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 5.5 mg/mL (10.89 mM; Need ultrasonic)
Chemical Name 1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
SMILES CC1=C(C=NN1C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCOCC5)C#N
Standard InChIKey BWZNJVZTAWBIFG-UHFFFAOYSA-N
Standard InChI InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Y-320

DescriptionY-320 is an orally active immunomodulator and inhibitor of IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

Y-320 Dilution Calculator

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Y-320 Molarity Calculator

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Preparing Stock Solutions of Y-320

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9802 mL 9.9008 mL 19.8016 mL 39.6032 mL 49.504 mL
5 mM 0.396 mL 1.9802 mL 3.9603 mL 7.9206 mL 9.9008 mL
10 mM 0.198 mL 0.9901 mL 1.9802 mL 3.9603 mL 4.9504 mL
50 mM 0.0396 mL 0.198 mL 0.396 mL 0.7921 mL 0.9901 mL
100 mM 0.0198 mL 0.099 mL 0.198 mL 0.396 mL 0.495 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Y-320

Y-320 is a new phenylpyrazoleanilide immunomodulator [1].

Immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.

Y-320 is a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells induced by IL-15 with IC50 values of 20-60 nM [1].

In type II collagen-induced arthritis (CIA) mice, oral administration of Y-320 (0.3-3 mg/kg) reduced IL-17 mRNA expression and significantly inhibited the development of joint destruction and arthritis. The combination of Y-320 with anti-murine tumor necrosis factor-α (TNF-α) monoclonal antibody exhibited a synergistic effect. In cynomolgus monkeys, Y-320 (0.3-1 mg/kg) relieved CIA. These results suggested that Y-320 could be a useful candidate for therapy of rheumatoid arthritis (RA) [1].

Reference:
[1].  Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel), 2013, 7(1): 1-17.

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References on Y-320

A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys.[Pubmed:24366113]

Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-alpha monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys. Our results suggest that Y-320, an orally active inhibitor for IL-17 production, provides a useful therapy for RA.

Description

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.

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