ZM 226600

Kir6 (KATP) channel opener CAS# 147695-92-9

ZM 226600

Catalog No. BCC6831----Order now to get a substantial discount!

Product Name & Size Price Stock
ZM 226600: 5mg $92 In Stock
ZM 226600: 10mg Please Inquire In Stock
ZM 226600: 20mg Please Inquire Please Inquire
ZM 226600: 50mg Please Inquire Please Inquire
ZM 226600: 100mg Please Inquire Please Inquire
ZM 226600: 200mg Please Inquire Please Inquire
ZM 226600: 500mg Please Inquire Please Inquire
ZM 226600: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of ZM 226600

Number of papers citing our products

Chemical structure

ZM 226600

3D structure

Chemical Properties of ZM 226600

Cas No. 147695-92-9 SDF Download SDF
PubChem ID 5240098 Appearance Powder
Formula C16H14F3NO4S M.Wt 373.35
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
Chemical Name N-[4-(benzenesulfonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
SMILES CC(C(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2)(C(F)(F)F)O
Standard InChIKey LJLXQHHFAKVTNP-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H14F3NO4S/c1-15(22,16(17,18)19)14(21)20-11-7-9-13(10-8-11)25(23,24)12-5-3-2-4-6-12/h2-10,22H,1H3,(H,20,21)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of ZM 226600

DescriptionPotent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties.

ZM 226600 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

ZM 226600 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of ZM 226600

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6785 mL 13.3923 mL 26.7845 mL 53.569 mL 66.9613 mL
5 mM 0.5357 mL 2.6785 mL 5.3569 mL 10.7138 mL 13.3923 mL
10 mM 0.2678 mL 1.3392 mL 2.6785 mL 5.3569 mL 6.6961 mL
50 mM 0.0536 mL 0.2678 mL 0.5357 mL 1.0714 mL 1.3392 mL
100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.5357 mL 0.6696 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on ZM 226600

Low nitrogen stress stimulating the indole-3-acetic acid biosynthesis of Serratia sp. ZM is vital for the survival of the bacterium and its plant growth-promoting characteristic.[Pubmed:27803972]

Arch Microbiol. 2017 Apr;199(3):425-432.

Serratia sp. ZM is a plant growth-promoting (PGP) bacterial strain isolated from the rhizospheric soil of Populus euphratica in northwestern China. In this study, low nitrogen supply significantly stimulated the production of indole-3-acetic acid (IAA) in Serratia sp.ZM. The inoculation of the bacterium to wheat seedlings improved plant growth compared with the uninoculated group, and the stimulating effect was more prominent under low nitrogen stress. Inactivation of the predicted key gene in the IAA biosynthesis pathway impaired IAA production and significantly hampered mutant growth in poor medium. Furthermore, the IAA-deficient mutant lost the PGP effect under either normal or low nitrogen conditions in plant experiments. This study revealed the significant impact of environmental nitrogen levels on IAA production in the PGP strain and the vital effect of IAA on resistance physiology of both the bacterium and host plant. The characteristics of Serratia sp. ZM also indicated its application potential as a biofertilizer for plants, especially those suffering from poor nitrogen soil.

ZM-66, a new podophyllotoxin derivative inhibits proliferation and induces apoptosis in K562/ADM cells.[Pubmed:25264886]

Chin Med Sci J. 2014 Sep;29(3):174-9.

OBJECTIVE: To investigate the anti-tumor effect of ZM-66 on multidrug-resistant leukemic cell line K562/ADM. METHODS: The K562/ADM cells were treated with varying concentrations (0, 1, 2, 4 x 10(-)(3) mmol/L) of ZM-66 or etoposide for 24 hours. The proliferation was detected by Sulforhodamine B Sodium Salt (SRB) assay and apoptosis was detected by flow cytometry analysis and fluorescent staining. In addition, the expression levels of p53 and bax genes in K562/ADM cells were detected by RT-PCR analysis. The level of P-glycoprotein (P-gp), P53 and Bax protein in K562/ADM cells were detected by Western blot assay. RESULTS: SRB assay demonstrated that etoposide had little inhibitory effect on K562/ADM cells, whereas ZM-66 (1, 2, 4 x 10(-)(3) mmol/L) had significantly inhibitory effect on K562/ADM cells (all P<0.01). The acridine orange/propidium iodide dual staining showed that there were typical condensation of chromatin and nuclear fragmentation nuclei with red color in ZM-66 treated cells. Flow cytometric analysis showed that there was a significantly increase of apoptotic cells in K562/ADM cells after treated with ZM-66. RT-PCR showed that the p53 and bax mRNA expression levels in K562/ADM cells treated with ZM-66 at 1, 2, 4 x 10(-)(3) mmol/L were higher than those in the cell without treatment. Western blot showed that the P53 and Bax protein expression levels in K562/ADM cells treated with ZM-66 at 2, 4 x 10(-)(3) mmol/L were higher than those in the cell without treatment. But the P-gp protein expression level in K562/ADM cells treated with ZM-66 at 2, 4 x 10(-)(3) mmol/L was gradually lower than those in the cell without treatment. CONCLUSION: ZM-66 is able to induce cell death by apoptosis in vitro, as a result of the reverse of the apoptosis resistance in drug-resistant K562/ADM cells by modulating expression of key factors associated with apoptosis induction.

[New metalloendopeptidase of Morganella morganii ZM].[Pubmed:25895364]

Bioorg Khim. 2014 Nov-Dec;40(6):682-7.

Proteolytic activity which is inhibited in the presence of o-phenanthroline was found in M. morganii ZM. Intracellular proteases of M. morganii ZM unlimited split musculoskeletal actin in contrast to grimelysin. Several proteolitic proteins of M. morganii ZM cells were identified by zymography with gelatin. Metalloproteinase of M. morganii ZM cell lysate was purified by hydrophobic chromatography fractionation. The molecular weight of the protein was 35 kDa.

Keywords:

ZM 226600,147695-92-9,Natural Products,Potassium Channel, buy ZM 226600 , ZM 226600 supplier , purchase ZM 226600 , ZM 226600 cost , ZM 226600 manufacturer , order ZM 226600 , high purity ZM 226600

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: