dl-Aloesol

CAS# 104871-04-7

dl-Aloesol

Catalog No. BCN7265----Order now to get a substantial discount!

Product Name & Size Price Stock
dl-Aloesol: 5mg $748 In Stock
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Quality Control of dl-Aloesol

Number of papers citing our products

Chemical structure

dl-Aloesol

3D structure

Chemical Properties of dl-Aloesol

Cas No. 104871-04-7 SDF Download SDF
PubChem ID 5318230 Appearance Powder
Formula C13H14O4 M.Wt 234.25
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromen-4-one
SMILES CC1=CC(=CC2=C1C(=O)C=C(O2)CC(C)O)O
Standard InChIKey ZYCNQWOKCMJKEZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H14O4/c1-7-3-9(15)5-12-13(7)11(16)6-10(17-12)4-8(2)14/h3,5-6,8,14-15H,4H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of dl-Aloesol

The secondary metabolites of endophytic fungus HCCB06030.

Biological Activity of dl-Aloesol

Descriptiondl-Aloesol is a natural product from the secondary metabolites of endophytic fungus HCCB06030.

Protocol of dl-Aloesol

Structure Identification
Chem Pharm Bull (Tokyo). 1991 Mar;39(3):704-8.

Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain.[Pubmed: 2070451]


METHODS AND RESULTS:
By anaerobic incubation with a bacterial mixture from human feces, aloesin (aloeresin B; 1) was converted to 2-acetonyl-7-hydroxy-5-methylchromone (aloesone; 3) and dl-7-hydroxy-2-(2'-hydroxypropyl)-5-methylchromone (aloesol; 4a + 4b) through a cleavage of the C-glucosyl bond, followed by reduction of the acetonyl side chain. An analogous compound, aloeresin A (2), was converted to p-coumaric acid and aloesin (1), the latter being subsequently transformed to aloesone (3) and dl-Aloesol (4a + 4b). On the other hand, 7-O-methylated derivatives (7, 5a and 5b) of aloesin and of 8-C-glucosylaloesol were not cleaved to the corresponding aglycones, suggesting the importance of a free hydroxy group adjacent to the C-glucosyl group in the molecule for the bacterial cleavage of aloesin derivatives.
CONCLUSIONS:
This is the first report on the cleavage of the C-glycosyl bond of chromone C-glucosides by intestinal bacteria.

dl-Aloesol Dilution Calculator

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dl-Aloesol Molarity Calculator

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Preparing Stock Solutions of dl-Aloesol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.2689 mL 21.3447 mL 42.6894 mL 85.3789 mL 106.7236 mL
5 mM 0.8538 mL 4.2689 mL 8.5379 mL 17.0758 mL 21.3447 mL
10 mM 0.4269 mL 2.1345 mL 4.2689 mL 8.5379 mL 10.6724 mL
50 mM 0.0854 mL 0.4269 mL 0.8538 mL 1.7076 mL 2.1345 mL
100 mM 0.0427 mL 0.2134 mL 0.4269 mL 0.8538 mL 1.0672 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on dl-Aloesol

Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain.[Pubmed:2070451]

Chem Pharm Bull (Tokyo). 1991 Mar;39(3):704-8.

By anaerobic incubation with a bacterial mixture from human feces, aloesin (aloeresin B; 1) was converted to 2-acetonyl-7-hydroxy-5-methylchromone (aloesone; 3) and dl-7-hydroxy-2-(2'-hydroxypropyl)-5-methylchromone (aloesol; 4a + 4b) through a cleavage of the C-glucosyl bond, followed by reduction of the acetonyl side chain. An analogous compound, aloeresin A (2), was converted to p-coumaric acid and aloesin (1), the latter being subsequently transformed to aloesone (3) and dl-Aloesol (4a + 4b). On the other hand, 7-O-methylated derivatives (7, 5a and 5b) of aloesin and of 8-C-glucosylaloesol were not cleaved to the corresponding aglycones, suggesting the importance of a free hydroxy group adjacent to the C-glucosyl group in the molecule for the bacterial cleavage of aloesin derivatives. This is the first report on the cleavage of the C-glycosyl bond of chromone C-glucosides by intestinal bacteria.

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