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ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

CAS# 77658-46-9

ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

Catalog No. BCN1355----Order now to get a substantial discount!

Product Name & Size Price Stock
ent-11,16-Epoxy-15-hydroxykauran-19-oic acid: 5mg $886 In Stock
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Quality Control of ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

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Chemical structure

ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

3D structure

Chemical Properties of ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

Cas No. 77658-46-9 SDF Download SDF
PubChem ID 102004619 Appearance Powder
Formula C20H30O4 M.Wt 334.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,4S,5R,9R,10S,11S,13R,14R,16S)-16-hydroxy-5,9,13-trimethyl-12-oxapentacyclo[11.2.1.111,14.01,10.04,9]heptadecane-5-carboxylic acid
SMILES CC12CCCC(C1CCC34C2C5CC(C3)C(C4O)(O5)C)(C)C(=O)O
Standard InChIKey RNEBMVMFRKVVMY-GOCTUUHOSA-N
Standard InChI InChI=1S/C20H30O4/c1-17-6-4-7-18(2,16(22)23)13(17)5-8-20-10-11-9-12(14(17)20)24-19(11,3)15(20)21/h11-15,21H,4-10H2,1-3H3,(H,22,23)/t11-,12-,13-,14-,15+,17+,18+,19+,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

The herbs of Nouelia insignis

ent-11,16-Epoxy-15-hydroxykauran-19-oic acid Dilution Calculator

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ent-11,16-Epoxy-15-hydroxykauran-19-oic acid Molarity Calculator

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Preparing Stock Solutions of ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL 59.7907 mL 74.7384 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL 11.9581 mL 14.9477 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL 5.9791 mL 7.4738 mL
50 mM 0.0598 mL 0.299 mL 0.5979 mL 1.1958 mL 1.4948 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5979 mL 0.7474 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on ent-11,16-Epoxy-15-hydroxykauran-19-oic acid

Induction of laryngeal cancer cell death by Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid.[Pubmed:20146336]

Head Neck. 2010 Nov;32(11):1506-18.

BACKGROUND: Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F) is known to exhibit antitumor activity, but its mechanism is not completely understood. 5F has not been tested in laryngeal cancer. METHODS: Two laryngeal cancer cell lines were treated with 5F. Cell death was analyzed by MTT [3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide] and Annexin V assay. Nuclear factor kappa beta (NF-kappaB)- and apoptosis-related molecules were examined. RESULTS: 5F induced laryngeal cancer cell death in a dose-dependent manner. The Annexin V assay and the measurement of cleavage of procaspase-3 and poly(ADP-ribose) polymerase demonstrated that the 5F-induced cell death was mainly apoptotic. 5F slightly reduced the basal level of NF-kappaB, but significantly suppressed the inducible NF-kappaB by reducing its transcriptional activity, protecting its inhibitory subunit IkappaBalpha from degradation, and suppressing its level in the nucleus. 5F also inhibited pro-proliferative and anti-apoptotic molecules but promoted pro-apoptotic Bax. CONCLUSIONS: 5F induces apoptosis of laryngeal cancer cells by inhibiting NF-kappaB activation/induction, suppressing pro-proliferative and anti-apoptotic molecules, and promoting pro-apoptotic Bax.

[ROS is not involved in induction of cell death by Ent-11 alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid in HepG2 cells].[Pubmed:20707199]

Zhongguo Zhong Yao Za Zhi. 2010 May;35(10):1287-91.

OBJECTIVE: To identify the role of reactive oxygen species (ROS) formation on cell death induced by Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) in HepG2 cells. METHOD: MTT assay was used to determine the effect of 5F on proliferation of HepG2 cells, and apoptotic morphological changes were assessed using Hoechst/PI assay. To evaluate intracellular ROS levels, a GENMED kit was used. HepG2 cells were treated with 5F for 24 h or with 1 mmol x L(-1) GSH for 1 h prior to treatment with 5F for 24 h, then cytoplasmic mono- and oligonucleosomes were assessed with Cell Death Detection ELISA kit. RESULT: The cytotoxicity of 5F on HepG2 cells was elevated with increasing 5F concentrations, as evidenced by the cell viability assay, and the apoptotic changes such as chromatin condensation were confirmed by Hoechst/PI staining. The decrease in ROS generation was observed in HepG2 cells following treatment with 5F. Cytoplasmic mono- and oligonucleosomes induced by 5F were not changed by decreasing basal level of ROS-mediated signaling with GSH. Further more, induction of ROS production by cisplatinum (CDDP) was canceled by treatment with 5F and 5F revealed a additive effect to cell killing by CDDP. CONCLUSION: 5F can not only induce apoptosis through non-ROS-depandent pathway, and can abate oxidant stress.

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