iMAC2

MAC inhibitor CAS# 335166-36-4

iMAC2

Catalog No. BCC2396----Order now to get a substantial discount!

Product Name & Size Price Stock
iMAC2: 5mg $127 In Stock
iMAC2: 10mg Please Inquire In Stock
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Quality Control of iMAC2

Number of papers citing our products

Chemical structure

iMAC2

3D structure

Chemical Properties of iMAC2

Cas No. 335166-36-4 SDF Download SDF
PubChem ID 9869276 Appearance Powder
Formula C19H20Br2FN3 M.Wt 469.2
Type of Compound N/A Storage Desiccate at -20°C
Solubility Limited solubility
Chemical Name 3,6-dibromo-9-(2-fluoro-3-piperazin-1-ylpropyl)carbazole
SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)F
Standard InChIKey BSTYITXHUQTYBA-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H20Br2FN3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24/h1-4,9-10,15,23H,5-8,11-12H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

iMAC2 Dilution Calculator

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iMAC2 Molarity Calculator

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Preparing Stock Solutions of iMAC2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1313 mL 10.6564 mL 21.3129 mL 42.6257 mL 53.2822 mL
5 mM 0.4263 mL 2.1313 mL 4.2626 mL 8.5251 mL 10.6564 mL
10 mM 0.2131 mL 1.0656 mL 2.1313 mL 4.2626 mL 5.3282 mL
50 mM 0.0426 mL 0.2131 mL 0.4263 mL 0.8525 mL 1.0656 mL
100 mM 0.0213 mL 0.1066 mL 0.2131 mL 0.4263 mL 0.5328 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

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Auburn University

Yale University

Worcester Polytechnic Institute

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Universidade da Beira Interior

The Institute of Cancer Research

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University of Amsterdam

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The University of Michigan
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Sun Yat-sen University
Universite de Paris
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Deemed University
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Auckland University
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The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on iMAC2

Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

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References on iMAC2

Implantable cardiac defibrillators and sudden death in recent onset nonischemic cardiomyopathy: results from IMAC2.[Pubmed:22939035]

J Card Fail. 2012 Sep;18(9):675-81.

BACKGROUND: Given the potential for recovery in recent onset nonischemic cardiomyopathy (ROCM), the timing and need for implantable cardioverter-defibrillator (ICDs) remains controversial. We examined the utilization of ICDs and the impact on survival for subjects with ROCM. METHODS AND RESULTS: An National Heart, Lung, and Blood Institute sponsored registry enrolled 373 subjects with ROCM, all with a left ventricular ejection fraction (LVEF)

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