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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN6435	Icariside F2
1. Icariside F2 displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM. 2. Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities.
BCN7788	Nantenine
1. (+)-Nantenine has antagonistic activities on alpha1-adrenoceptors, alpha2-adrenoceptors and 5-HT2A receptors in pithed rats. 2. Nantenine displays cytotoxicity against SMMC-7721 with the IC50 value of 70.08 ± 4.63 uM. 3. Nantenine is an acetylcholinesterase inhibitor. 4. Nantenine functions as an effective antagonist against a wide range of MDMA-induced effects in mice. 5. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca2+-influx into the cell.
BCN7789	Ustusolate E
1. Ustusolate E exhibits moderate cytotoxicity against A549 and HL-60 cells with the IC50 value of 9.0 microM.
BCN7790	Euphol
1. Euphol, a novel cannabinoid agonist, prevents inflammatory and neuropathic persistent pain in rodents. 2. Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. 3. Euphol has anti-inflammatory action, it can prevent experimental autoimmune encephalomyelitis in mice.
BCN7791	Crenulatin
1. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L group, respectively; the mechanism is related to the alterations of Fas/Bcl-2 expression and caspase-3 activity.
BCN7792	1,6-O,O-Diacetylbritannilactone
1. 1,6-O,O-Diacetylbritannilactone has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. 2. 1,6-O,O-Diacetylbritannilactone has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. 3. 1,6-O,O-Diacetylbritannilactone exhibits potent antitumor activity against several human cancer cell lines.
BCN7793	Hernandezine
1. Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). 2. Hernandezine is a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells. 3. Hernandezine inhibits calcium-depletion stimulated calcium entry in human and bovine endothelial cells. 4. Hernandezine induces autophagic cell death in drug-resistant cancers.
BCN7794	Retusin
1. Retusin behaves as pre- and postemergent herbicides. 2. Retusin exhibits potent free-radical-scavenging capacities as well as efficient inhibition of cellular melanogenesis. 3. Retusin is a weak inhibitor of ATP synthesis.