Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 457 - 464 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2401 | GRI 977143 |
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Selective lysophosphatidic acid 2 (LPA<sub>2</sub>) receptor non-lipid agonist (EC<sub>50</sub> = 3.3 <span class='symbol'>μ</span>M). Does not activate other LPA GPCRs at concentrations up to 10 <span class='symbol'>μ</span>M. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.
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| BCC2402 | Mdivi 1 |
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Selective inhibitor of Dnm1 GTPase (IC<sub>50</sub> = 1 - 10 <span class='symbol'>μ</span>M); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.
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| BCC2403 | Melphalan |
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DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC<sub>50</sub> values are 0.074 and 0.77 <span class='symbol'>μ</span>g/ml for sequential dosing and single dosing respectively).
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| BCC2404 | NQDI 1 |
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Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC<sub>50</sub> = 3 <span class='symbol'>μ</span>M, K<sub>i</sub> = 500 nM).
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| BCC2405 | TLQP 21 |
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VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. Increases energy expenditure and prevents early phase diet-induced diabetes.
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| BCC2406 | CP 31398 dihydrochloride |
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p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
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| BCC2407 | Cyclic Pifithrin-α hydrobromide |
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Cyclic analog of pifithrin-<span class='symbol'>α</span>, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC<sub>50</sub> = 2.01 <span class ='symbol'>μ</span>M). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
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| BCC2408 | HLI 373 |
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Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
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