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1beta,10beta-Epoxydesacetoxymatricarin

CAS# 124020-39-9

1beta,10beta-Epoxydesacetoxymatricarin

Catalog No. BCN7307----Order now to get a substantial discount!

Product Name & Size Price Stock
1beta,10beta-Epoxydesacetoxymatricarin: 5mg $886 In Stock
1beta,10beta-Epoxydesacetoxymatricarin: 10mg Please Inquire In Stock
1beta,10beta-Epoxydesacetoxymatricarin: 20mg Please Inquire Please Inquire
1beta,10beta-Epoxydesacetoxymatricarin: 50mg Please Inquire Please Inquire
1beta,10beta-Epoxydesacetoxymatricarin: 100mg Please Inquire Please Inquire
1beta,10beta-Epoxydesacetoxymatricarin: 200mg Please Inquire Please Inquire
1beta,10beta-Epoxydesacetoxymatricarin: 500mg Please Inquire Please Inquire
1beta,10beta-Epoxydesacetoxymatricarin: 1000mg Please Inquire Please Inquire

Quality Control of 1beta,10beta-Epoxydesacetoxymatricarin

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Chemical structure

1beta,10beta-Epoxydesacetoxymatricarin

3D structure

Chemical Properties of 1beta,10beta-Epoxydesacetoxymatricarin

Cas No. 124020-39-9 SDF Download SDF
PubChem ID 14313751 Appearance Powder
Formula C15H18O4 M.Wt 262.30
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,3S,6S,7S,10S,11R)-3,7,12-trimethyl-2,9-dioxatetracyclo[9.3.0.01,3.06,10]tetradec-12-ene-8,14-dione
SMILES CC1C2CCC3(C4(O3)C(C2OC1=O)C(=CC4=O)C)C
Standard InChIKey WLWQUBMOSXUFJB-YFRBHOLXSA-N
Standard InChI InChI=1S/C15H18O4/c1-7-6-10(16)15-11(7)12-9(8(2)13(17)18-12)4-5-14(15,3)19-15/h6,8-9,11-12H,4-5H2,1-3H3/t8-,9-,11+,12-,14-,15+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1beta,10beta-Epoxydesacetoxymatricarin

The herbs of Achillea wilhelmsii.

Biological Activity of 1beta,10beta-Epoxydesacetoxymatricarin

Description1. 1beta,10beta-Epoxydesacetoxymatricarin shows high anti-hypercholesterolemic potential.
TargetsHMG-CoA Reductase | TNF-α | MMP(e.g.TIMP)

1beta,10beta-Epoxydesacetoxymatricarin Dilution Calculator

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1beta,10beta-Epoxydesacetoxymatricarin Molarity Calculator

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Preparing Stock Solutions of 1beta,10beta-Epoxydesacetoxymatricarin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8124 mL 19.0621 mL 38.1243 mL 76.2486 mL 95.3107 mL
5 mM 0.7625 mL 3.8124 mL 7.6249 mL 15.2497 mL 19.0621 mL
10 mM 0.3812 mL 1.9062 mL 3.8124 mL 7.6249 mL 9.5311 mL
50 mM 0.0762 mL 0.3812 mL 0.7625 mL 1.525 mL 1.9062 mL
100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.7625 mL 0.9531 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1beta,10beta-Epoxydesacetoxymatricarin

Intermolecular exciton coupling and vibronic effects in solid-state circular dichroism: a case study.[Pubmed:23203006]

Phys Chem Chem Phys. 2013 Jan 21;15(3):795-802.

The electronic circular dichroism (CD) spectrum of the sesquiterpenoid 1beta,10beta-Epoxydesacetoxymatricarin (1) measured in the microcrystalline solid state differs from the solution one in the appearance of a pronounced vibrational fine structure in the long-wavelength region (n-pi* enone transition) and of a new moderately intense band in the pi-pi* region. TDDFT CD calculations were run on input structures derived from the X-ray geometry of 1 to reproduce the impact of exciton-type couplings between proximate molecules in the crystals. The vibrational structure of the CD spectrum was also reproduced for the isolated molecule by modelling the potential energy surfaces at the harmonic level and taking into account Duschinsky and Herzberg-Teller effects.

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed:27023504]

Molecules. 2016 Mar 25;21(4):404.

This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators. The extracts and fractions of A. wilhelmsii were thoroughly analyzed using high performance liquid chromatography (HPLC), and the total content of phenols and flavonoids was determined. The hypoglycemic activity was evaluated in vivo using alloxan-induced diabetic mice. The effect upon inflammatory mediators was evaluated in vitro using the human monocytic leukemia cell line (THP-1). The anti-hypercholesterolemic activity was evaluated in vitro using the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase assay kit. The water extract (WE)-treated group showed the highest reduction in the fasting blood glucose levels (FBGL). The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-alpha). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified. Out of the five compounds in the CF, 1beta,10beta-Epoxydesacetoxymatricarin (CP1) and leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.

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