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2'-Hydroxy-5'-methoxyacetophenone

CAS# 705-15-7

2'-Hydroxy-5'-methoxyacetophenone

Catalog No. BCN4270----Order now to get a substantial discount!

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2'-Hydroxy-5'-methoxyacetophenone: 5mg $6 In Stock
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Quality Control of 2'-Hydroxy-5'-methoxyacetophenone

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Chemical structure

2'-Hydroxy-5'-methoxyacetophenone

3D structure

Chemical Properties of 2'-Hydroxy-5'-methoxyacetophenone

Cas No. 705-15-7 SDF Download SDF
PubChem ID 69714 Appearance Powder
Formula C9H10O3 M.Wt 166.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-(2-hydroxy-5-methoxyphenyl)ethanone
SMILES CC(=O)C1=C(C=CC(=C1)OC)O
Standard InChIKey MLIBGOFSXXWRIY-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2'-Hydroxy-5'-methoxyacetophenone

The roots of Cynanchum paniculatum

Biological Activity of 2'-Hydroxy-5'-methoxyacetophenone

Description2'-Hydroxy-5'-methoxyacetophenone [LD50 =1.03 μg/cm(2)] shows acaricidal potentials against D. farinae.
TargetsAntifection
In vitro

Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals.[Pubmed: 23855621]

J Agric Food Chem. 2013 Aug 7;61(31):7568-73.


METHODS AND RESULTS:
On the basis of the LD50 values against D. farinae, 3'-methoxyacetophenone (0.41 μg/cm(2)) was 89.9 times more toxic than DEET (36.87 μg/cm(2)), followed by 4'-methoxyacetophenone (0.52 μg/cm(2)), 2'-methoxyacetophenone (0.75 μg/cm(2)), 2'-Hydroxy-5'-methoxyacetophenone (1.03 μg/cm(2)), 2'-hydroxy-4'-methoxyacetophenone (1.29 μg/cm(2)), acetophenone (1.48 μg/cm(2)), 2'-hydroxyacetophenone (1.74 μg/cm(2)), 2',5'-dimethoxyacetophenone (1.87 μg/cm(2)), 2',4'-dimethoxyacetophenone (2.10 μg/cm(2)), and benzyl benzoate (9.92 μg/cm(2)). In regard to structure-activity relationships between acaricidal activity and functional radicals (hydroxyl and methoxy groups) on the acetophenone skeleton, a monomethoxy group (2'-, 3'-, and 4'-methoxyacetone) on the acetophenone skeleton was more toxic than were the other groups (2',4'- and 2',5'-dimethoxyacetophenone, 2'- and 4'-hydroxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-Hydroxy-5'-methoxyacetophenone, and 4'-hydroxy-3'-methoxyacetophenone).
CONCLUSIONS:
These results indicated that acaricidal activity against three mite species changed with the introduction of functional radicals (hydroxyl and methoxy groups) onto the acetophenone skeleton.

2'-Hydroxy-5'-methoxyacetophenone Dilution Calculator

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2'-Hydroxy-5'-methoxyacetophenone Molarity Calculator

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Preparing Stock Solutions of 2'-Hydroxy-5'-methoxyacetophenone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.0168 mL 30.0842 mL 60.1685 mL 120.3369 mL 150.4212 mL
5 mM 1.2034 mL 6.0168 mL 12.0337 mL 24.0674 mL 30.0842 mL
10 mM 0.6017 mL 3.0084 mL 6.0168 mL 12.0337 mL 15.0421 mL
50 mM 0.1203 mL 0.6017 mL 1.2034 mL 2.4067 mL 3.0084 mL
100 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.2034 mL 1.5042 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2'-Hydroxy-5'-methoxyacetophenone

Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals.[Pubmed:23855621]

J Agric Food Chem. 2013 Aug 7;61(31):7568-73.

This study evaluated the acaricidal activities of acetophenone and its derivatives for their potentials as natural acaricides using an impregnated fumigant bioassay against Dermatophagoides spp. and Tyrophagus putrescentiae . On the basis of the LD50 values against D. farinae, 3'-methoxyacetophenone (0.41 mug/cm(2)) was 89.9 times more toxic than DEET (36.87 mug/cm(2)), followed by 4'-methoxyacetophenone (0.52 mug/cm(2)), 2'-methoxyacetophenone (0.75 mug/cm(2)), 2'-hydroxy-5'-methoxyacetophenone (1.03 mug/cm(2)), 2'-hydroxy-4'-methoxyacetophenone (1.29 mug/cm(2)), acetophenone (1.48 mug/cm(2)), 2'-hydroxyacetophenone (1.74 mug/cm(2)), 2',5'-dimethoxyacetophenone (1.87 mug/cm(2)), 2',4'-dimethoxyacetophenone (2.10 mug/cm(2)), and benzyl benzoate (9.92 mug/cm(2)). In regard to structure-activity relationships between acaricidal activity and functional radicals (hydroxyl and methoxy groups) on the acetophenone skeleton, a monomethoxy group (2'-, 3'-, and 4'-methoxyacetone) on the acetophenone skeleton was more toxic than were the other groups (2',4'- and 2',5'-dimethoxyacetophenone, 2'- and 4'-hydroxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-hydroxy-5'-methoxyacetophenone, and 4'-hydroxy-3'-methoxyacetophenone). These results indicated that acaricidal activity against three mite species changed with the introduction of functional radicals (hydroxyl and methoxy groups) onto the acetophenone skeleton.

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