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3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

CAS# 125537-92-0

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Catalog No. BCN6136----Order now to get a substantial discount!

Product Name & Size Price Stock
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 5mg $914 In Stock
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 10mg Please Inquire In Stock
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 20mg Please Inquire Please Inquire
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 50mg Please Inquire Please Inquire
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 100mg Please Inquire Please Inquire
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 200mg Please Inquire Please Inquire
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 500mg Please Inquire Please Inquire
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone: 1000mg Please Inquire Please Inquire

Quality Control of 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Number of papers citing our products

Chemical structure

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

3D structure

Chemical Properties of 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cas No. 125537-92-0 SDF Download SDF
PubChem ID 10337658 Appearance Yellow powder
Formula C17H14O8 M.Wt 346.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,5-dihydroxy-4-methoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
SMILES COC1=C(C=C(C=C1O)C2=CC(=O)C3=C(C(=C(C=C3O2)O)OC)O)O
Standard InChIKey KPONYCCDEVQZMR-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H14O8/c1-23-16-9(19)3-7(4-10(16)20)12-5-8(18)14-13(25-12)6-11(21)17(24-2)15(14)22/h3-6,19-22H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

The aerial parts of Artemisia salsoloides

Biological Activity of 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Description1. 5,7,3',5'-Tetrahydroxy-6,4'-dimethoxyflavone exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. 2. 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase.
TargetsHIV | Topoisomerase

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone Dilution Calculator

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3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone Molarity Calculator

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Preparing Stock Solutions of 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8877 mL 14.4383 mL 28.8767 mL 57.7534 mL 72.1917 mL
5 mM 0.5775 mL 2.8877 mL 5.7753 mL 11.5507 mL 14.4383 mL
10 mM 0.2888 mL 1.4438 mL 2.8877 mL 5.7753 mL 7.2192 mL
50 mM 0.0578 mL 0.2888 mL 0.5775 mL 1.1551 mL 1.4438 mL
100 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.5775 mL 0.7219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

DNA topoisomerase IIalpha inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata.[Pubmed:22155186]

Fitoterapia. 2012 Mar;83(2):368-72.

Four new flavones, 5,2'-dihydroxy-7,3',4',5'-tetramethoxyflavone (1), 5,2',5'-trihydroxy-7,3',4'-trimethoxyflavone (2), 5,7,2',5'-tetrahydroxy-6,3',4'-trimethoxyflavone (3) and 5,2',5'-trihydroxy-6,7,3',4'-tetramethoxyflavone (4), along with the known 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (5), 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase IIalpha activity, which may be responsible for the observed cytotoxicity. Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using (Tat/rev)MC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase.

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