Cedrelone

CAS# 1254-85-9

Cedrelone

Catalog No. BCN6135----Order now to get a substantial discount!

Product Name & Size Price Stock
Cedrelone: 5mg $828 In Stock
Cedrelone: 10mg Please Inquire In Stock
Cedrelone: 20mg Please Inquire Please Inquire
Cedrelone: 50mg Please Inquire Please Inquire
Cedrelone: 100mg Please Inquire Please Inquire
Cedrelone: 200mg Please Inquire Please Inquire
Cedrelone: 500mg Please Inquire Please Inquire
Cedrelone: 1000mg Please Inquire Please Inquire

Quality Control of Cedrelone

Number of papers citing our products

Chemical structure

Cedrelone

3D structure

Chemical Properties of Cedrelone

Cas No. 1254-85-9 SDF Download SDF
PubChem ID 3083689 Appearance Powder
Formula C26H30O5 M.Wt 422.5
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C(=O)C=CC2(C1=C(C(=O)C3(C2CCC4(C35C(O5)CC4C6=COC=C6)C)C)O)C)C
Standard InChIKey OQMUOVSEPOBWMK-MFNRWJBWSA-N
Standard InChI InChI=1S/C26H30O5/c1-22(2)17(27)7-9-23(3)16-6-10-24(4)15(14-8-11-30-13-14)12-18-26(24,31-18)25(16,5)21(29)19(28)20(22)23/h7-9,11,13,15-16,18,28H,6,10,12H2,1-5H3/t15-,16+,18?,23?,24-,25?,26?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cedrelone

The barks of Cedrela toona

Biological Activity of Cedrelone

Description1. Cedrelone exhibits antifeedant activity. 2. Cedrelone and its derivatives exert antimicrobial activities, bromohydroxy cedrelone and Michael adduct show good antifungal activity. 3. Cedrelone and dysobinin show significant cytotoxicity against cancer cell lines, such as -60, SMMC-7721, A-549, MCF-7 and SW480. 4. Cedrelone is a very potent inducers of apoptosis, it can cause cell cycle arrest. 5. Cedrelone has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fasciatus.
TargetsMMP(e.g.TIMP) | Antifection

Cedrelone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Cedrelone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Cedrelone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3669 mL 11.8343 mL 23.6686 mL 47.3373 mL 59.1716 mL
5 mM 0.4734 mL 2.3669 mL 4.7337 mL 9.4675 mL 11.8343 mL
10 mM 0.2367 mL 1.1834 mL 2.3669 mL 4.7337 mL 5.9172 mL
50 mM 0.0473 mL 0.2367 mL 0.4734 mL 0.9467 mL 1.1834 mL
100 mM 0.0237 mL 0.1183 mL 0.2367 mL 0.4734 mL 0.5917 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Cedrelone

Effects of limonoid cedrelone on MDA-MB-231 breast tumor cells in vitro.[Pubmed:23869780]

Anticancer Agents Med Chem. 2013 Dec;13(10):1645-53.

Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compounds which could be the basis for the design of new anti-tumor drugs, with fewer side effects than the conventional chemotherapy used currently. Cedrelone is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that Cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of Cedrelone to inhibit MMP activity. We also demonstrate that Cedrelone is able to induce apoptosis in MDA-MB-231 cells. There are only a few works investigating the effect of limonoids in cellular processes closely related to tumor progression such as adhesion, migration and invasion. To the best of our knowledge, this is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.

Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line.[Pubmed:21269253]

Anticancer Agents Med Chem. 2010 Dec;10(10):769-76.

Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and Cedrelone) caused cell cycle arrest while only the limonoids gedunin and Cedrelone were found to be very potent inducers of apoptosis.

Limonoids from the leaves of Toona ciliata var. yunnanensis.[Pubmed:22277739]

Phytochemistry. 2012 Apr;76:141-9.

Twelve limonoids, toonayunnanins A-L (1-12) and eleven known compounds (13-23) were isolated from the leaves of Toona ciliata var. yunnanensis, and their structures were elucidated by means of extensive spectroscopic analyses, particularly 1D and 2D NMR techniques. The inhibitory effects of all the isolated compounds were evaluated on human tumor cell lines, such as HL-60, SMMC-7721, A-549, MCF-7 and SW480. Cedrelone (13) and dysobinin (18) showed significant cytotoxicity, and toonayunnanin B (2) and epoxyazadiradione (14), were found to be slightly cytotoxic against the above cell lines. Furthermore, this study provides valuable information for the chemotaxonomy of T. ciliata varieties.

Photooxidation of cedrelone, a tetranortriterpenoid from Toona ciliata.[Pubmed:11045715]

Photochem Photobiol. 2000 Oct;72(4):464-6.

Cedrelone, a tetranortriterpenoid on photolysis by UV light yields a true photooxidation product 3 [14 beta,15beta,22beta,23beta-diepoxy-6-hydroxy-1,5, 20(22)-meliatriene-2,7,21-trione] whose structure is well established by NMR studies and confirmed by X-ray crystallography, along with product 4 [14 beta,15beta-epoxy-6,23-dihydroxy-1,5,20(22)-meliatriene-2,7, 21-trione]. Addition of rose bengal increases the rate of photooxidation whereas DABCO decreases rate of photolysis proving the involvement of singlet oxygen in the photooxygenation. Both the photoproducts exhibited antifeedant activity.

Keywords:

Cedrelone,1254-85-9,Natural Products, buy Cedrelone , Cedrelone supplier , purchase Cedrelone , Cedrelone cost , Cedrelone manufacturer , order Cedrelone , high purity Cedrelone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: