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3,5-Dihydroxyergosta-7,22-dien-6-one

CAS# 14858-07-2

3,5-Dihydroxyergosta-7,22-dien-6-one

Catalog No. BCN1658----Order now to get a substantial discount!

Product Name & Size Price Stock
3,5-Dihydroxyergosta-7,22-dien-6-one: 5mg $748 In Stock
3,5-Dihydroxyergosta-7,22-dien-6-one: 10mg Please Inquire In Stock
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3,5-Dihydroxyergosta-7,22-dien-6-one: 500mg Please Inquire Please Inquire
3,5-Dihydroxyergosta-7,22-dien-6-one: 1000mg Please Inquire Please Inquire

Quality Control of 3,5-Dihydroxyergosta-7,22-dien-6-one

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Chemical structure

3,5-Dihydroxyergosta-7,22-dien-6-one

3D structure

Chemical Properties of 3,5-Dihydroxyergosta-7,22-dien-6-one

Cas No. 14858-07-2 SDF Download SDF
PubChem ID 71307325 Appearance Powder
Formula C28H44O3 M.Wt 428.7
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-3,5-dihydroxy-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
SMILES CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C2=CC(=O)C4(C3(CCC(C4)O)C)O)C
Standard InChIKey KAIVGEVOBNIWLR-NSMOMACISA-N
Standard InChI InChI=1S/C28H44O3/c1-17(2)18(3)7-8-19(4)22-9-10-23-21-15-25(30)28(31)16-20(29)11-14-27(28,6)24(21)12-13-26(22,23)5/h7-8,15,17-20,22-24,29,31H,9-14,16H2,1-6H3/b8-7+/t18-,19+,20?,22+,23-,24-,26+,27+,28?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,5-Dihydroxyergosta-7,22-dien-6-one

The fruit body of Ganoderma lucidum

Biological Activity of 3,5-Dihydroxyergosta-7,22-dien-6-one

Description1. 3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), respectively.

3,5-Dihydroxyergosta-7,22-dien-6-one Dilution Calculator

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3,5-Dihydroxyergosta-7,22-dien-6-one Molarity Calculator

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Preparing Stock Solutions of 3,5-Dihydroxyergosta-7,22-dien-6-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3,5-Dihydroxyergosta-7,22-dien-6-one

A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213.[Pubmed:29194412]

Mar Drugs. 2017 Dec 1;15(12). pii: md15120375.

A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: beta-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus Neosartorya fennelliae KUFA 0811. Nine previously reported metabolites, including a chromanol derivative (3), (3beta, 5alpha, 22E), 3,5-Dihydroxyergosta-7,22-dien-6-one (4), byssochlamic acid, hopan-3beta,22-diol, chevalone C, sartorypyrone B, helvolic acid, lumichrome and the alkaloid harmane were isolated from the culture of the marine-sponge associated fungus Neosartorya tsunodae KUFC 9213. Paecilin E (1), dankasterone A (2), a chromanol derivative (3), (3beta, 5alpha, 22E)-3,5-Dihydroxyergosta-7,22-dien-6-one (4), hopan-3beta,22-diol (5), lumichrome (6), and harmane (7) were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. While paecilin E (1) was active against S. aureus ATCC 29213 and E. faecalis ATCC 29212, dankastetrone A (2) was only effective against E. faecalis ATCC 29212 and the multidrug-resistant VRE E. faecalis A5/102. Both compounds neither inhibit biofilm mass production in any of the strains at the concentrations tested nor exhibit synergistic association with antibiotics.

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