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3-O-Methylquercetin tetraacetate

CAS# 1486-69-7

3-O-Methylquercetin tetraacetate

Catalog No. BCN1659----Order now to get a substantial discount!

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Quality Control of 3-O-Methylquercetin tetraacetate

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Chemical structure

3-O-Methylquercetin tetraacetate

3D structure

Chemical Properties of 3-O-Methylquercetin tetraacetate

Cas No. 1486-69-7 SDF Download SDF
PubChem ID 10005544 Appearance Yellow powder
Formula C24H20O11 M.Wt 484.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [2-acetyloxy-4-(5,7-diacetyloxy-3-methoxy-4-oxochromen-2-yl)phenyl] acetate
SMILES CC(=O)OC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)OC(=O)C)OC(=O)C)OC)OC(=O)C
Standard InChIKey IRJPBMYKKVBCHS-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-O-Methylquercetin tetraacetate

The herbs of Croton cascarilloides

Biological Activity of 3-O-Methylquercetin tetraacetate

Description1. Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness .
TargetsPDE | IL Receptor | TNF-α

3-O-Methylquercetin tetraacetate Dilution Calculator

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3-O-Methylquercetin tetraacetate Molarity Calculator

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Preparing Stock Solutions of 3-O-Methylquercetin tetraacetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0644 mL 10.322 mL 20.6441 mL 41.2882 mL 51.6102 mL
5 mM 0.4129 mL 2.0644 mL 4.1288 mL 8.2576 mL 10.322 mL
10 mM 0.2064 mL 1.0322 mL 2.0644 mL 4.1288 mL 5.161 mL
50 mM 0.0413 mL 0.2064 mL 0.4129 mL 0.8258 mL 1.0322 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.4129 mL 0.5161 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-O-Methylquercetin tetraacetate

Potent suppressive effects of 3-O-methylquercetin 5,7,3',4'-O-tetraacetate on ovalbumin-induced airway hyperresponsiveness.[Pubmed:17823872]

Planta Med. 2007 Sep;73(11):1156-62.

We investigated the suppressive effects of 3-O-methylquercetin 5,7,3',4'- O-tetraacetate (QMTA), a more-potent phosphodiesterase (PDE)3/4 inhibitor than quercetin 3-O-methyl ether (3-MQ), which has been reported to have the potential for treating asthma, against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR). The IC50 value of QMTA for PDE3 was significantly less than that for PDE4. According to the Lineweaver-Burk analysis, QMTA (1-10 microM) competitively inhibited PDE3 and PDE4 activities. The Ki values were 0.9+/-0.3 (n=5) and 3.9+/-0.5 (n=5) microM, respectively, which significantly differed from each other, suggesting that QMTA has higher affinity for PDE3 than for PDE4. QMTA (3-10 microM) concentration-dependently relaxed the baseline level, and significantly inhibited cumulative OVA (10-100 microg/mL)-induced contractions in isolated sensitized guinea pig trachealis suggesting that QMTA has bronchodilator and inhibiting effects on mast cell degranulation. After the secondary challenge, the AHR was measured in unrestrained OVA-sensitized mice, with nebulized methacholine (MCh, 6.25-50 mg/mL), by barometric plethysmography using a whole-body plethysmograph. In the present results, QMTA (3-10 micromol/kg, I. P.) dose-dependently attenuated the enhanced pause (Penh) value induced by MCh (25-50 mg/mL). QMTA (3-10 micromol/kg, I. P.) also significantly inhibited total inflammatory cells, macrophages, neutrophils, lymphocytes, and eosinophils in BALF after determination of Penh values. It also significantly suppressed the release of interleukin (IL)-2, IL-4, IL-5, IFN-gamma, and TNF-alpha, with the exception that 3 micromol/kg QMTA did not suppress the releases of IL-5. QMTA even at 1 micromol/kg significantly inhibited eosinophils, IL-2, and TNF-alpha. In conclusion, our results strongly suggest that QMTA has greater potential than 3-MQ for the treatment of asthma.

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