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3,8'-Biapigenin

CAS# 101140-06-1

3,8'-Biapigenin

Catalog No. BCN5825----Order now to get a substantial discount!

Product Name & Size Price Stock
3,8'-Biapigenin: 5mg $322 In Stock
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Quality Control of 3,8'-Biapigenin

Number of papers citing our products

Chemical structure

3,8'-Biapigenin

3D structure

Chemical Properties of 3,8'-Biapigenin

Cas No. 101140-06-1 SDF Download SDF
PubChem ID 10414856 Appearance Yellow powder
Formula C30H18O10 M.Wt 538.5
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms 3,8''-Biapigenin
Solubility Soluble in acetone and chloroform
Chemical Name 3-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
SMILES C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(OC5=CC(=CC(=C5C4=O)O)O)C6=CC=C(C=C6)O)O
Standard InChIKey IQAMTZLKUHMPPE-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,8'-Biapigenin

The herbs of Hypericum perforatum L.

Biological Activity of 3,8'-Biapigenin

Description3, 8''-Biapigenin can modulate intracellular ROS production.
TargetsROS
In vitro

Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb.[Pubmed: 19203769 ]

Phytochemistry. 2009 Jan;70(2):244-9.


METHODS AND RESULTS:
The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3,8'-Biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs).
CONCLUSIONS:
The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production.

3,8'-Biapigenin Dilution Calculator

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3,8'-Biapigenin Molarity Calculator

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Preparing Stock Solutions of 3,8'-Biapigenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.857 mL 9.2851 mL 18.5701 mL 37.1402 mL 46.4253 mL
5 mM 0.3714 mL 1.857 mL 3.714 mL 7.428 mL 9.2851 mL
10 mM 0.1857 mL 0.9285 mL 1.857 mL 3.714 mL 4.6425 mL
50 mM 0.0371 mL 0.1857 mL 0.3714 mL 0.7428 mL 0.9285 mL
100 mM 0.0186 mL 0.0929 mL 0.1857 mL 0.3714 mL 0.4643 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3,8'-Biapigenin

Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb.[Pubmed:19203769]

Phytochemistry. 2009 Jan;70(2):244-9.

The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8''-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production.

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