Larixinol

CAS# 101046-79-1

Larixinol

Catalog No. BCN6484----Order now to get a substantial discount!

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Larixinol: 5mg $903 In Stock
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Chemical structure

Larixinol

3D structure

Chemical Properties of Larixinol

Cas No. 101046-79-1 SDF Download SDF
PubChem ID 21676379 Appearance Powder
Formula C30H22O10 M.Wt 542.5
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,2'R,3R,3'R)-3',4,5',6-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)spiro[2H-1-benzofuran-3,9'-3,4-dihydro-2H-furo[2,3-h]chromene]-8'-one
SMILES C1C(C(OC2=C3C(=CC(=C21)O)OC(=O)C34C(OC5=CC(=CC(=C45)O)O)C6=CC=C(C=C6)O)C7=CC=C(C=C7)O)O
Standard InChIKey RNDNBGULZNCSNB-LYFQOWASSA-N
Standard InChI InChI=1S/C30H22O10/c31-15-5-1-13(2-6-15)26-21(36)11-18-19(34)12-23-25(27(18)40-26)30(29(37)39-23)24-20(35)9-17(33)10-22(24)38-28(30)14-3-7-16(32)8-4-14/h1-10,12,21,26,28,31-36H,11H2/t21-,26-,28-,30-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Larixinol

The heartwoods of Pinus armandii

Biological Activity of Larixinol

Description1. Larixinol shows moderate inhibitory activities against LPS-induced NO production in macrophages with an IC(50) value of 60.0 microg/mL. 2. Larixinol shows antioxidant activity.
TargetsNO

Larixinol Dilution Calculator

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Larixinol Molarity Calculator

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Preparing Stock Solutions of Larixinol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Larixinol

Two new spirobiflavonoids from Abies chensiensis with moderate NO production inhibitory activity.[Pubmed:19499503]

Planta Med. 2009 Nov;75(14):1534-7.

Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound Larixinol ( 1). The structures of spirobiflavonoids 1- 3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of Larixinol ( 1) was confirmed by X-ray crystallographic analysis. Compounds 1- 3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol ( 1) showed moderate effects, with an IC(50) value of 60.0 microg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 microg/mL.

Yucca schidigera bark: phenolic constituents and antioxidant activity.[Pubmed:15165156]

J Nat Prod. 2004 May;67(5):882-5.

Two new phenolic constituents with unusual spirostructures, named yuccaols D (1) and E (2), were isolated from the MeOH extract of Yucca schidigera bark. Their structures were established by spectroscopic (ESIMS and NMR) analysis. The new yuccaols D and E, along with resveratrol (3), trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene (4), yuccaols A-C (5-7), yuccaone A (8), Larixinol (9), the MeOH extract of Yucca schidigera bark, and the phenolic portion of this extract, were assayed for antioxidant activity by measuring the free radical scavenging effects using two different assays, namely, the Trolox Equivalent Antioxidant Capacity (TEAC) assay and the coupled oxidation of beta-carotene and linoleic acid (autoxidation assay). The significant activities exhibited by the phenolic fraction and its constituents in both tests show the potential use of Y. schidigera as a source of antioxidant principles.

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