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4,4'-Di-O-methylellagic acid

CAS# 3374-77-4

4,4'-Di-O-methylellagic acid

Catalog No. BCN3709----Order now to get a substantial discount!

Product Name & Size Price Stock
4,4'-Di-O-methylellagic acid: 5mg Please Inquire In Stock
4,4'-Di-O-methylellagic acid: 10mg Please Inquire In Stock
4,4'-Di-O-methylellagic acid: 20mg Please Inquire Please Inquire
4,4'-Di-O-methylellagic acid: 50mg Please Inquire Please Inquire
4,4'-Di-O-methylellagic acid: 100mg Please Inquire Please Inquire
4,4'-Di-O-methylellagic acid: 200mg Please Inquire Please Inquire
4,4'-Di-O-methylellagic acid: 500mg Please Inquire Please Inquire
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Quality Control of 4,4'-Di-O-methylellagic acid

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Chemical structure

4,4'-Di-O-methylellagic acid

3D structure

Chemical Properties of 4,4'-Di-O-methylellagic acid

Cas No. 3374-77-4 SDF Download SDF
PubChem ID 11580745 Appearance Powder
Formula C16H10O8 M.Wt 330.0
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=C(C2=C3C(=C1)C(=O)OC4=C3C(=CC(=C4O)OC)C(=O)O2)O
Standard InChIKey UMWZIZVOUZTAPW-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4,4'-Di-O-methylellagic acid

The peels of Punica granatum L.

Biological Activity of 4,4'-Di-O-methylellagic acid

Description1. 4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.
TargetsWnt/β-catenin

4,4'-Di-O-methylellagic acid Dilution Calculator

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4,4'-Di-O-methylellagic acid Molarity Calculator

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Preparing Stock Solutions of 4,4'-Di-O-methylellagic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0303 mL 15.1515 mL 30.303 mL 60.6061 mL 75.7576 mL
5 mM 0.6061 mL 3.0303 mL 6.0606 mL 12.1212 mL 15.1515 mL
10 mM 0.303 mL 1.5152 mL 3.0303 mL 6.0606 mL 7.5758 mL
50 mM 0.0606 mL 0.303 mL 0.6061 mL 1.2121 mL 1.5152 mL
100 mM 0.0303 mL 0.1515 mL 0.303 mL 0.6061 mL 0.7576 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 4,4'-Di-O-methylellagic acid

The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.[Pubmed:25758919]

J Pharmacol Exp Ther. 2015 May;353(2):433-44.

Ellagic acid (EA) and some derivatives have been reported to inhibit cancer cell proliferation, induce cell cycle arrest, and modulate some important cellular processes related to cancer. This study aimed to identify possible structure-activity relationships of EA and some in vivo derivatives in their antiproliferative effect on both human colon cancer and normal cells, and to compare this activity with that of other polyphenols. Our results showed that 4,4'-di-O-methylellagic acid (4,4'-DiOMEA) was the most effective compound in the inhibition of colon cancer cell proliferation. 4,4'-DiOMEA was 13-fold more effective than other compounds of the same family. In addition, 4,4'-DiOMEA was very active against colon cancer cells resistant to the chemotherapeutic agent 5-fluoracil, whereas no effect was observed in nonmalignant colon cells. Moreover, no correlation between antiproliferative and antioxidant activities was found, further supporting that structure differences might result in dissimilar molecular targets involved in their differential effects. Finally, microarray analysis revealed that 4,4'-DiOMEA modulated Wnt signaling, which might be involved in the potential antitumor action of this compound. Our results suggest that structural-activity differences between EA and 4,4'-DiOMEA might constitute the basis for a new strategy in anticancer drug discovery based on these chemical modifications.

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