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Demethyl tetrandrine

CAS# 33889-68-8

Demethyl tetrandrine

Catalog No. BCN2624----Order now to get a substantial discount!

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Chemical structure

Demethyl tetrandrine

3D structure

Chemical Properties of Demethyl tetrandrine

Cas No. 33889-68-8 SDF Download SDF
PubChem ID 321937 Appearance Cryst.
Formula C37H40N2O6 M.Wt 608.72
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC
Standard InChIKey IIQSJHUEZBTSAT-UHFFFAOYSA-N
Standard InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Demethyl tetrandrine

The roots of Stephania tetrandra S.Moore

Biological Activity of Demethyl tetrandrine

DescriptionDemethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively.
TargetsDNA/RNA Synthesis
In vitro

INHIBITION OF TETRANDRINE AND DEMETHYL TETRANDRINE ON DNA, RNA AND PROTEIN SYNTHESES OF LEUKEMIA 7712 AND SARCOMA 180 CELLS[Reference: WebLink]

《Chinese Pharmacological Bulletin》 1990-01


METHODS AND RESULTS:
The 50% inhibition doses ( ID50 ) of tetrandrine and Demethyl tetrandrine on DNA synthesis in L7712 and Sl80 cells are 2.6, 3 .5mg/ L and 27.5, 24.5mg/L respectively. The DNA synthesis inhibition is likely due to DNA template damage caused by both natural products. The inhibition of DNA, RNA and protein syntheses by tetrandrine or Demethyl tetrandrine increased with incubating time. The inhibiting activities of two natural products on DNA and RNA synthesis are s-tronger than on protein.
CONCLUSIONS:
There are no differences either in inhibiting activity or in inhibiting mechanism between two natural products.

Demethyl tetrandrine Dilution Calculator

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Demethyl tetrandrine Molarity Calculator

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Preparing Stock Solutions of Demethyl tetrandrine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6428 mL 8.214 mL 16.4279 mL 32.8558 mL 41.0698 mL
5 mM 0.3286 mL 1.6428 mL 3.2856 mL 6.5712 mL 8.214 mL
10 mM 0.1643 mL 0.8214 mL 1.6428 mL 3.2856 mL 4.107 mL
50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6571 mL 0.8214 mL
100 mM 0.0164 mL 0.0821 mL 0.1643 mL 0.3286 mL 0.4107 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania,exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.

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