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6-Aminoindole

CAS# 5318-27-4

6-Aminoindole

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Product Name & Size Price Stock
6-Aminoindole: 5mg $17 In Stock
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Quality Control of 6-Aminoindole

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Chemical structure

6-Aminoindole

3D structure

Chemical Properties of 6-Aminoindole

Cas No. 5318-27-4 SDF Download SDF
PubChem ID 256096 Appearance Powder
Formula C8H8N2 M.Wt 132
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1H-indol-6-amine
SMILES C1=CC(=CC2=C1C=CN2)N
Standard InChIKey MIMYTSWNVBMNRH-UHFFFAOYSA-N
Standard InChI InChI=1S/C8H8N2/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H,9H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

6-Aminoindole Dilution Calculator

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6-Aminoindole Molarity Calculator

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Preparing Stock Solutions of 6-Aminoindole

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 7.5758 mL 37.8788 mL 75.7576 mL 151.5152 mL 189.3939 mL
5 mM 1.5152 mL 7.5758 mL 15.1515 mL 30.303 mL 37.8788 mL
10 mM 0.7576 mL 3.7879 mL 7.5758 mL 15.1515 mL 18.9394 mL
50 mM 0.1515 mL 0.7576 mL 1.5152 mL 3.0303 mL 3.7879 mL
100 mM 0.0758 mL 0.3788 mL 0.7576 mL 1.5152 mL 1.8939 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Aminoindole

Discover 4beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.[Pubmed:30878833]

Eur J Med Chem. 2019 May 15;170:73-86.

The colchicine binding site of tubulin is an attractive molecular target domain for cancer therapies. However, there was no FDA approved drug for targeting colchicine domain. Our previous crystallography discovered that a potential binding site of alphaT5 loop-alphaH7 nearby colchicine domain was beneficial for introducing affinity fragment. In this work, benzo heterocycles (i.e., indole, indazole and quinoline) with the high affinity ability of alphaT5 loop-alphaH7 were chosen as affinity fragment to modify the molecule structure of podophyllotoxin for improving the tubulin binding affinity. 4beta-NH-(benzo heterocycles)-4-desoxy-podophyllotoxin were synchronously located at alpha/beta interface of tubulin through providing affinity fragment to alphaT5 loop-alphaH7 (i.e., alpha178Ser, alpha182Val, alpha241Phe) and colchicine domain (i.e., beta241Cys, beta124ASP). 4beta-NH-(6''-aminoindole)-4-desoxy-podophyllotoxin not only exhibited nanomolar antitumor potency in vitro but also destroyed solid tumor growth without lethal toxicity in vivo. The correctness of rational drug design was strictly demonstrated by bioactivity test.

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