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Methyocarbamol

CAS# 532-03-6

Methyocarbamol

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Quality Control of Methyocarbamol

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Chemical structure

Methyocarbamol

3D structure

Chemical Properties of Methyocarbamol

Cas No. 532-03-6 SDF Download SDF
PubChem ID 4107 Appearance Powder
Formula C11H15NO5 M.Wt 241.24
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 100 mg/mL (414.52 mM)
H2O : 4 mg/mL (16.58 mM; Need ultrasonic)
*"≥" means soluble, but saturation unknown.
Chemical Name [2-hydroxy-3-(2-methoxyphenoxy)propyl] carbamate
SMILES COC1=CC=CC=C1OCC(COC(=O)N)O
Standard InChIKey GNXFOGHNGIVQEH-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Methyocarbamol

DescriptionMethocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Target: Carbonic Anhydrase Methocarbamol is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is not hydrolyzed metabolically; metabolism is by Phase I ring hydroxylation and O-demethylation, followed by Phase II conjugation. All the major metabolites are unhydrolyzed carbamates. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm [1, 2].

References:
[1]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6. [2]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4.

Methyocarbamol Dilution Calculator

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Methyocarbamol Molarity Calculator

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Preparing Stock Solutions of Methyocarbamol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1452 mL 20.7262 mL 41.4525 mL 82.905 mL 103.6312 mL
5 mM 0.829 mL 4.1452 mL 8.2905 mL 16.581 mL 20.7262 mL
10 mM 0.4145 mL 2.0726 mL 4.1452 mL 8.2905 mL 10.3631 mL
50 mM 0.0829 mL 0.4145 mL 0.829 mL 1.6581 mL 2.0726 mL
100 mM 0.0415 mL 0.2073 mL 0.4145 mL 0.829 mL 1.0363 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Methyocarbamol

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.

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Description

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.

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