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6-Aminoquinoxaline

CAS# 6298-37-9

6-Aminoquinoxaline

Catalog No. BCC8767----Order now to get a substantial discount!

Product Name & Size Price Stock
6-Aminoquinoxaline: 5mg $17 In Stock
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Quality Control of 6-Aminoquinoxaline

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Chemical structure

6-Aminoquinoxaline

3D structure

Chemical Properties of 6-Aminoquinoxaline

Cas No. 6298-37-9 SDF Download SDF
PubChem ID 237859 Appearance Powder
Formula C8H7N3 M.Wt 145
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name quinoxalin-6-amine
SMILES C1=CC2=NC=CN=C2C=C1N
Standard InChIKey MSGRFBKVMUKEGZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C8H7N3/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,9H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

6-Aminoquinoxaline Dilution Calculator

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6-Aminoquinoxaline Molarity Calculator

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Preparing Stock Solutions of 6-Aminoquinoxaline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.8966 mL 34.4828 mL 68.9655 mL 137.931 mL 172.4138 mL
5 mM 1.3793 mL 6.8966 mL 13.7931 mL 27.5862 mL 34.4828 mL
10 mM 0.6897 mL 3.4483 mL 6.8966 mL 13.7931 mL 17.2414 mL
50 mM 0.1379 mL 0.6897 mL 1.3793 mL 2.7586 mL 3.4483 mL
100 mM 0.069 mL 0.3448 mL 0.6897 mL 1.3793 mL 1.7241 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Aminoquinoxaline

New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models.[Pubmed:27341519]

J Med Chem. 2016 Jul 14;59(13):6169-86.

Parkinson's disease (PD) is a neurodegenerative disorder of aging characterized by motor symptoms that result from the loss of midbrain dopamine neurons and the disruption of dopamine-mediated neurotransmission. There is currently no curative treatment for this disorder. To discover druggable neuroprotective compounds for dopamine neurons, we have designed and synthesized a second-generation of quinoxaline-derived molecules based on structure-activity relationship studies, which led previously to the discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c). Neuroprotection assessment in PD cellular models of our newly synthesized quinoxaline-derived compounds has led to the selection of a better hit compound, PAQ (4c). Extensive in vitro characterization of 4c showed that its neuroprotective action is partially attributable to the activation of reticulum endoplasmic ryanodine receptor channels. Most interestingly, 4c was able to attenuate neurodegeneration in a mouse model of PD, making this compound an interesting drug candidate for the treatment of this disorder.

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