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6-Methoxy-4-methylcoumarin

CAS# 6295-35-8

6-Methoxy-4-methylcoumarin

Catalog No. BCN6537----Order now to get a substantial discount!

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Quality Control of 6-Methoxy-4-methylcoumarin

Number of papers citing our products

Chemical structure

6-Methoxy-4-methylcoumarin

3D structure

Chemical Properties of 6-Methoxy-4-methylcoumarin

Cas No. 6295-35-8 SDF Download SDF
PubChem ID 223821 Appearance Powder
Formula C11H10O3 M.Wt 190.20
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-methoxy-4-methylchromen-2-one
SMILES CC1=CC(=O)OC2=C1C=C(C=C2)OC
Standard InChIKey KNGPIBWCWOQBEK-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H10O3/c1-7-5-11(12)14-10-4-3-8(13-2)6-9(7)10/h3-6H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-Methoxy-4-methylcoumarin

The herbs of Eupatorium pauciflorum

Biological Activity of 6-Methoxy-4-methylcoumarin

Description6-Methoxy-4-methylcoumarin is a natural product from Eupatorium pauciflorum.

Protocol of 6-Methoxy-4-methylcoumarin

Structure Identification
Journal of Molecular Structure, 2014 , 1061 (1) :175-80.

Study of dipole moments of some coumarin derivatives.[Reference: WebLink]

In this paper we report the dipole moments of two coumarin derivatives viz 6-Methoxy-4-methylcoumarin (6MMC) and 6-hydroxy-4-methylcoumarin (6HMC).
METHODS AND RESULTS:
Solvatochromic shift in absorption and emission spectra as a function of different solvent polarity parameter has been analyzed. With the help of this, ground and first excited state dipole moments of two coumarin derivatives have been calculated. Dipole moments are also estimated theoretically. The first excited state dipole moment of both the coumarin derivatives is higher than the ground state dipole moment indicating a substantial redistribution of π-electron density in the excited state.

6-Methoxy-4-methylcoumarin Dilution Calculator

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6-Methoxy-4-methylcoumarin Molarity Calculator

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Preparing Stock Solutions of 6-Methoxy-4-methylcoumarin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2576 mL 26.2881 mL 52.5762 mL 105.1525 mL 131.4406 mL
5 mM 1.0515 mL 5.2576 mL 10.5152 mL 21.0305 mL 26.2881 mL
10 mM 0.5258 mL 2.6288 mL 5.2576 mL 10.5152 mL 13.1441 mL
50 mM 0.1052 mL 0.5258 mL 1.0515 mL 2.103 mL 2.6288 mL
100 mM 0.0526 mL 0.2629 mL 0.5258 mL 1.0515 mL 1.3144 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Methoxy-4-methylcoumarin

Biochemical and Proteomic Characterization of Recombinant Human alpha/beta Hydrolase Domain 6.[Pubmed:30696836]

Sci Rep. 2019 Jan 29;9(1):890.

Human alpha/beta hydrolase domain 6 (hABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-AG), a potent agonist at both cannabinoid CB1 and CB2 receptors. In vivo modulation of ABHD6 expression has been shown to have potential therapeutic applications, making the enzyme a promising drug target. However, the lack of structural information on hABHD6 limits the discovery and design of selective inhibitors. We have performed E. coli expression, purification and activity profiling screening of different hABHD6 constructs and identified a truncated variant without N-terminal transmembrane (TM) domain, hDelta29-3-ABHD6, as the most promising protein for further characterization. The elimination of the TM domain did not affect 2-AG or fluorogenic arachidonoyl, 7-hydroxy-6-Methoxy-4-methylcoumarin ester (AHMMCE) substrates hydrolysis, suggesting that the TM is not essential for enzyme catalytic activity. The hDelta29-3-ABHD6 variant was purified in a single step using Immobilized Metal Affinity Chromatography (IMAC), in-solution trypsin digested, and proteomically characterized by Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS). The N-terminal peptide without methionine was identified indicating on a post-translational modification of the recombinant protein. The mechanism of inhibition of hABHD6 with AM6701 and WWL70 covalent probes was elucidated based on MS analysis of trypsin digested hABHD6 following the Ligand Assisted Protein Structure (LAPS) approach. We identified the carbamylated peptides containing catalytic serine (Ser(148)) suggesting a selective carbamylation of the enzyme by AM6701 or WWL70 and confirming an essential role of this residue in catalysis. The ability to produce substantial quantities of functional, pure hABHD6 will aid in the downstream structural characterization, and development of potent, selective inhibitors.

Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification.[Pubmed:18452279]

J Proteome Res. 2008 May;7(5):2158-64.

The serine hydrolase monoacylglycerol lipase (MGL) modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors. To characterize this key endocannabinoid enzyme by mass spectrometry-based proteomics, we first overexpressed recombinant hexa-histidine-tagged human MGL (hMGL) in Escherichia coli and purified it in a single chromatographic step with high yield (approximately 30 mg/L). With 2-AG as substrate, hMGL displayed an apparent V max of 25 micromol/(microg min) and K m of 19.7 microM, an affinity for 2-AG similar to that of native rat-brain MGL (rMGL) (Km=33.6 microM). hMGL also demonstrated a comparable affinity (Km approximately 8-9 microM) for the novel fluorogenic substrate, arachidonoyl, 7-hydroxy-6-Methoxy-4-methylcoumarin ester (AHMMCE), in a sensitive, high-throughput fluorometric MGL assay. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) unequivocably demonstrated the mass (34,126 Da) and purity of this hMGL preparation. After in-solution tryptic digestion, hMGL full proteomic characterization was carried out, which showed (1) an absence of intramolecular disulfide bridges in the functional, recombinant enzyme and (2) the post-translational removal of the enzyme's N-terminal methionine. Availability of sufficient quantities of pure, well-characterized hMGL will enable further molecular and structural profiling of this key endocannabinoid-system enzyme.

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