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6-Methoxyluteolin

CAS# 520-11-6

6-Methoxyluteolin

Catalog No. BCN3613----Order now to get a substantial discount!

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Quality Control of 6-Methoxyluteolin

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Chemical structure

6-Methoxyluteolin

3D structure

Chemical Properties of 6-Methoxyluteolin

Cas No. 520-11-6 SDF Download SDF
PubChem ID 5317284 Appearance Yellow powder
Formula C16H12O7 M.Wt 316.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Eupafolin; 6-Methoxyluteolin; 3',4',5,7-Tetrahydroxy 6-methoxyflavone
Solubility Soluble in methanol; slightly soluble in water
Chemical Name 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
SMILES COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O)O
Standard InChIKey FHHSEFRSDKWJKJ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-Methoxyluteolin

1 Arnica sp. 2 Artemisia sp. 3 Baccharis sp. 4 Centaurea sp. 5 Cirsium sp. 6 Eupatorium sp. 7 Inula sp. 8 Lippia sp. 9 Salvia sp. 10 Scutellaria sp. 11 Tanacetum sp.

Biological Activity of 6-Methoxyluteolin

Description1. 6-Methoxyluteolin has antioxidant activity. 2. 6-Methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
TargetsCalcium Channel | Histamine Receptor

6-Methoxyluteolin Dilution Calculator

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6-Methoxyluteolin Molarity Calculator

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Preparing Stock Solutions of 6-Methoxyluteolin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1616 mL 15.8078 mL 31.6156 mL 63.2311 mL 79.0389 mL
5 mM 0.6323 mL 3.1616 mL 6.3231 mL 12.6462 mL 15.8078 mL
10 mM 0.3162 mL 1.5808 mL 3.1616 mL 6.3231 mL 7.9039 mL
50 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.2646 mL 1.5808 mL
100 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Methoxyluteolin

6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcepsilonRI alpha chain expression.[Pubmed:22561855]

J Microbiol Biotechnol. 2012 May;22(5):622-7.

Mast cells and basophils are important effector cells in immunoglobulin-E (IgE)-mediated allergic reactions. Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcepsilonRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcepsilonRI alpha chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcepsilonRI alpha chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively. Therefore, these results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcepsilonRI alpha chain.

Description

Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells.

Keywords:

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