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8-Amino-7-oxononanoic acid

CAS# 4707-58-8

8-Amino-7-oxononanoic acid

Catalog No. BCN1778----Order now to get a substantial discount!

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Chemical structure

8-Amino-7-oxononanoic acid

3D structure

Chemical Properties of 8-Amino-7-oxononanoic acid

Cas No. 4707-58-8 SDF Download SDF
PubChem ID 173 Appearance Powder
Formula C9H17NO3 M.Wt 187.24
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 8-amino-7-oxononanoic acid
SMILES CC(C(=O)CCCCCC(=O)O)N
Standard InChIKey GUAHPAJOXVYFON-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8-Amino-7-oxononanoic acid

The Penicillium chrysogenum

Biological Activity of 8-Amino-7-oxononanoic acid

Description1. 8-Amino-7-oxononanoic acid is a precursor of 7,8-Diaminopelargonic acid (DAPA), and 7,8-diaminopelargonic acid aminotransferase (DAPA AT) is a potential drug target in Mycobacterium tuberculosis.

8-Amino-7-oxononanoic acid Dilution Calculator

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8-Amino-7-oxononanoic acid Molarity Calculator

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Preparing Stock Solutions of 8-Amino-7-oxononanoic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.3407 mL 26.7037 mL 53.4074 mL 106.8148 mL 133.5185 mL
5 mM 1.0681 mL 5.3407 mL 10.6815 mL 21.363 mL 26.7037 mL
10 mM 0.5341 mL 2.6704 mL 5.3407 mL 10.6815 mL 13.3518 mL
50 mM 0.1068 mL 0.5341 mL 1.0681 mL 2.1363 mL 2.6704 mL
100 mM 0.0534 mL 0.267 mL 0.5341 mL 1.0681 mL 1.3352 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 8-Amino-7-oxononanoic acid

Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications.[Pubmed:19345718]

Biochimie. 2009 Jul;91(7):826-34.

7,8-Diaminopelargonic acid aminotransferase (DAPA AT), a potential drug target in Mycobacterium tuberculosis, transforms 8-Amino-7-oxononanoic acid (KAPA) into DAPA. We have designed an analytical method to measure the enantiomeric excess of KAPA, based on the derivatization of its amine function, by ortho-phtalaldehyde and N-acetyl-l-cysteine, followed by high pressure liquid chromatography separation. Using this methodology and enantiopure samples of KAPA it appeared that racemization of KAPA occurs rapidly (half-lives from 1 to 8 h) not only in 4 M HCl but more importantly in the usual pH range, from 7 to 9. Furthermore, we showed that racemic KAPA, and not enantiopure KAPA, was used in all previous studies. The only valid enantioselective synthesis of KAPA is that reported by Lucet et al. (1996) Tetrahedron: Asymmetry 7, 985-988. KAPA is produced as a pure (S)-enantiomer by KAPA synthase and by microbial production and DAPA AT only uses (S)-KAPA as substrate. However, (R)-KAPA is an inhibitor of this enzyme. It binds to the pyridoxal 5'-phosphate form (K(i1) = 5.9 +/- 0.2 microM) and to the pyridoxamine 5'-phosphate form (K(i2) = 1.7 +/- 0.2 microM) of M. tuberculosis DAPA AT. Molecular modeling showed that (R)-KAPA forms specific hydrogen bonds with T309 and the phosphate group of the cofactor of DAPA AT. Desmethyl-KAPA (8-amino-7-oxooctanoic acid), an achiral analog of KAPA, is also a potent inhibitor of M. tuberculosis DAPA AT. This molecule binds to the enzyme in a similar way than (R)-KAPA with the following constants: K(i1) = 4.2 +/- 0.2 microM, and K(i2) = 0.9 +/- 0.2 microM. These findings pave the way to the design of new antimycobacterial drugs.

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