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8alpha-Hydroxyhirsutinolide

CAS# 1394156-45-6

8alpha-Hydroxyhirsutinolide

Catalog No. BCN7111----Order now to get a substantial discount!

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8alpha-Hydroxyhirsutinolide: 5mg $886 In Stock
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Quality Control of 8alpha-Hydroxyhirsutinolide

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Chemical structure

8alpha-Hydroxyhirsutinolide

3D structure

Chemical Properties of 8alpha-Hydroxyhirsutinolide

Cas No. 1394156-45-6 SDF Download SDF
PubChem ID 70690654 Appearance Powder
Formula C15H20O6 M.Wt 296.31
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2E,8S,10R,11S)-8,11-dihydroxy-6-(hydroxymethyl)-1,10-dimethyl-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-5-one
SMILES CC1CC(C2=C(C(=O)OC2=CC3(CCC1(O3)O)C)CO)O
Standard InChIKey HGVUPZFNJFDVQM-HEQUYQGPSA-N
Standard InChI InChI=1S/C15H20O6/c1-8-5-10(17)12-9(7-16)13(18)20-11(12)6-14(2)3-4-15(8,19)21-14/h6,8,10,16-17,19H,3-5,7H2,1-2H3/b11-6+/t8-,10+,14-,15+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8alpha-Hydroxyhirsutinolide

The flowers of Vernonia cinerea.

Biological Activity of 8alpha-Hydroxyhirsutinolide

Description1. 8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
TargetsNO | TNF-α | NF-kB

8alpha-Hydroxyhirsutinolide Dilution Calculator

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8alpha-Hydroxyhirsutinolide Molarity Calculator

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Preparing Stock Solutions of 8alpha-Hydroxyhirsutinolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3748 mL 16.8742 mL 33.7484 mL 67.4969 mL 84.3711 mL
5 mM 0.675 mL 3.3748 mL 6.7497 mL 13.4994 mL 16.8742 mL
10 mM 0.3375 mL 1.6874 mL 3.3748 mL 6.7497 mL 8.4371 mL
50 mM 0.0675 mL 0.3375 mL 0.675 mL 1.3499 mL 1.6874 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 8alpha-Hydroxyhirsutinolide

Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.[Pubmed:22850207]

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.

Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8alpha-Hydroxyhirsutinolide (2), and a new naturally occurring derivative, 8alpha-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 and 4-9). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison with the structure of compound 1, whose relative stereochemistry was determined by X-ray analysis. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activity. Compounds 1, 2, 4, 5, and 9 inhibited TNF-alpha-induced NF-kappaB activity with IC(50) values of 3.1, 1.9, 0.6, 5.2, and 1.6 muM, respectively; compounds 4 and 6-9 exhibited significant NO inhibitory activity with IC(50) values of 2.0, 1.5, 1.2, 2.7, and 2.4 muM, respectively.

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