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Amisulpride hydrochloride

Dopamine D2/D3 receptor antagonist CAS# 81342-13-4

Amisulpride hydrochloride

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Chemical structure

Amisulpride hydrochloride

3D structure

Chemical Properties of Amisulpride hydrochloride

Cas No. 81342-13-4 SDF Download SDF
PubChem ID 10046897 Appearance Powder
Formula C17H28ClN3O4S M.Wt 405.94
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;hydrochloride
SMILES CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC.Cl
Standard InChIKey XFOYXFDTUMXXFP-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H27N3O4S.ClH/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3;/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Amisulpride hydrochloride Dilution Calculator

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Amisulpride hydrochloride Molarity Calculator

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Preparing Stock Solutions of Amisulpride hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4634 mL 12.3171 mL 24.6342 mL 49.2684 mL 61.5855 mL
5 mM 0.4927 mL 2.4634 mL 4.9268 mL 9.8537 mL 12.3171 mL
10 mM 0.2463 mL 1.2317 mL 2.4634 mL 4.9268 mL 6.1585 mL
50 mM 0.0493 mL 0.2463 mL 0.4927 mL 0.9854 mL 1.2317 mL
100 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.4927 mL 0.6159 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Amisulpride hydrochloride

Amisulpride hydrochloride is an atypical antagonist of dopamine D2/D3 receptor with Ki values of 2.8±0.4nM and 3.2±0.3nM for D2 and D3 receptor subtypes, respectively [1].

Amisulpride hydrochloride has shown high affinity to the cloned and stably transfected human dopamine D2 with Ki values of 2.8±0.4nM and 3.2±0.3nM for D2 and D3 receptor subtypes, respectively. Amisulpride hydrochloride has been reported to inhibit radioligand binding to native dopamine D2 receptor in membranes from the rat striatum with an IC50 value of 21nM. Besides, Amisulpride hydrochloride has been revealed to displace [3H]raclopride binding in vivo with an ED50 value of 17.3±1.86mg/kg in the rat limbic system. In addition, Amisulpride hydrochloride has been noted to inhibit quinpirole-induced [3H]thymidine with an IC50 value of 22±3nM [1].

References:
[1] Schoemaker H1, Claustre Y, Fage D, Rouquier L, Chergui K, Curet O, Oblin A, Gonon F, Carter C, Benavides J, Scatton B.Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97.

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Description

Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.

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