Aricine

CAS# 482-91-7

Aricine

Catalog No. BCN5576----Order now to get a substantial discount!

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Aricine: 5mg $765 In Stock
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Quality Control of Aricine

Number of papers citing our products

Chemical structure

Aricine

3D structure

Chemical Properties of Aricine

Cas No. 482-91-7 SDF Download SDF
PubChem ID 251575 Appearance Powder
Formula C22H26N2O4 M.Wt 382.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=C4C=C(C=C5)OC
Standard InChIKey DTDADHMBRZKXSC-GKASHWOUSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aricine

The herbs of Rauvolfia vomitoria Afzel.

Biological Activity of Aricine

DescriptionAricine has cytotoxicity.
In vitro

In vitro cytotoxicity testing of natural products using guinea‐pig ear keratinocytes[Reference: WebLink]

Phytotherapy Research,1988,2(1):25-29.


METHODS AND RESULTS:
A simple test is described in which the inhibition of uptake of [G-3H]thymidine into guinea-pig ear keratinocytes in vitro, has been used as an assessment for cytotoxicity of a series of alkaloids. The alkaloids tested include emetine, colchicine, coronaridine, ajmaline, Aricine, vincristine, leurosine, quinamine, 3-epiquinamine, quinine, quinidinone, cichonidine, berberine and atropine.

Protocol of Aricine

Structure Identification
Natural Product Communications, 2012, 7(11):1441-1444.

A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets.[Reference: WebLink]


METHODS AND RESULTS:
Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known alkaloids, tetrahydroalstonine (1), Aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.

Aricine Dilution Calculator

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Aricine Molarity Calculator

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Preparing Stock Solutions of Aricine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6144 mL 13.0719 mL 26.1438 mL 52.2876 mL 65.3595 mL
5 mM 0.5229 mL 2.6144 mL 5.2288 mL 10.4575 mL 13.0719 mL
10 mM 0.2614 mL 1.3072 mL 2.6144 mL 5.2288 mL 6.5359 mL
50 mM 0.0523 mL 0.2614 mL 0.5229 mL 1.0458 mL 1.3072 mL
100 mM 0.0261 mL 0.1307 mL 0.2614 mL 0.5229 mL 0.6536 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aricine

Alkaloids from Rauwolfia cubana Stem Bark.[Pubmed:17262416]

Planta Med. 1989 Jun;55(3):283-5.

Six indole alkaloids, tetrahydroalstonine, Aricine, 16- EPI-affinine, ajmaline, amerovolfine, and amerovolficine have been isolated from the ethanolic extract of the stem bark of RAUWOLFIA CUBANA A. DC. Amerovolfine ( N(alpha)-demethylaccedine) and amerovolficine (16-demethoxy-carbonylpagicerine) are new alkaloids related to 16- EPI-affinine, and their structures have been determined by spectroscopic analysis.

Application of pH-zone-refining countercurrent chromatography for the separation of indole alkaloids from Aspidosperma rigidum Rusby.[Pubmed:24192149]

J Chromatogr A. 2013 Dec 6;1319:166-71.

Species of Aspidosperma (Apocynaceae) are characterized by the occurrence of indole alkaloids, but few recent reports on Aspidosperma rigidum Rusby chemical constituents were found. The present work shows the application of pH-zone refining countercurrent chromatography on the separation of alkaloids from the barks of A. rigidum. In this study, the dichloromethane extract was fractionated with the solvent system composed of methyl-tert-butyl ether and water with different concentrations of the retainer triethylamine in the organic stationary phase and formic or hydrochloric acids as eluters in the aqueous mobile phase, in order to evaluate the most suitable condition. In each experiment, from circa 200mg of the dichloromethane extract of A. rigidum, three major alkaloids were isolated and identified as 3alpha-Aricine (circa 17mg), isoreserpiline (ca. 22mg) and 3beta-reserpiline (ca. 40mg), with relative purity of 79%, 89% and 82% respectively, in a one-step separation of 2h. Two of them - 3alpha-Aricine and isoreserpiline - were isolated and identified for the first time in this species.

A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets.[Pubmed:23285803]

Nat Prod Commun. 2012 Nov;7(11):1441-4.

Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known alkaloids, tetrahydroalstonine (1), Aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.

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