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Nordalbergin

CAS# 482-82-6

Nordalbergin

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Quality Control of Nordalbergin

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Chemical structure

Nordalbergin

3D structure

Chemical Properties of Nordalbergin

Cas No. 482-82-6 SDF Download SDF
PubChem ID 5320203 Appearance Powder
Formula C15H10O4 M.Wt 254
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6,7-dihydroxy-4-phenylchromen-2-one
SMILES C1=CC=C(C=C1)C2=CC(=O)OC3=CC(=C(C=C23)O)O
Standard InChIKey TZRNJQYCOSMOJS-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H10O4/c16-12-6-11-10(9-4-2-1-3-5-9)7-15(18)19-14(11)8-13(12)17/h1-8,16-17H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Nordalbergin

The heartwood of Dalbergia sissoo.

Biological Activity of Nordalbergin

In vitro

Effect of coumarins on HL-60 cell differentiation.[Pubmed: 10953319]

Anticancer Res. 2000 Jul-Aug;20(4):2505-12.


METHODS AND RESULTS:
Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, Nordalbergin, 6,7-dihydroxy-4-methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage.
CONCLUSIONS:
The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.

Nordalbergin Dilution Calculator

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Nordalbergin Molarity Calculator

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Preparing Stock Solutions of Nordalbergin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.937 mL 19.685 mL 39.3701 mL 78.7402 mL 98.4252 mL
5 mM 0.7874 mL 3.937 mL 7.874 mL 15.748 mL 19.685 mL
10 mM 0.3937 mL 1.9685 mL 3.937 mL 7.874 mL 9.8425 mL
50 mM 0.0787 mL 0.3937 mL 0.7874 mL 1.5748 mL 1.9685 mL
100 mM 0.0394 mL 0.1969 mL 0.3937 mL 0.7874 mL 0.9843 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Nordalbergin

Effect of coumarins on HL-60 cell differentiation.[Pubmed:10953319]

Anticancer Res. 2000 Jul-Aug;20(4):2505-12.

Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, Nordalbergin, 6,7-dihydroxy-4-methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.

Description

Nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo. Nordalbergin shows strong activity in the induction of differentiation of HL-60.

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