(-)-Asarinin

CAS# 133-04-0

(-)-Asarinin

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Chemical structure

(-)-Asarinin

3D structure

Chemical Properties of (-)-Asarinin

Cas No. 133-04-0 SDF Download SDF
PubChem ID 5204 Appearance White powder
Formula C20H18O6 M.Wt 354.35
Type of Compound Lignans Storage Desiccate at -20°C
Synonyms Desgeranyloxyarmatumin; (-)-Episesamin; Xanthoxylin S
Solubility Soluble in chloroform
Chemical Name 5-[3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole
SMILES C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6
Standard InChIKey PEYUIKBAABKQKQ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (-)-Asarinin

1 Callitris sp. 2 Sesamum sp. 3 Zanthoxylum sp.

Biological Activity of (-)-Asarinin

DescriptionAsarinin, a mammalian lignan precursor, has immunosuppression activity in vitro. Asarinin can decrease peripheral blood concentration of interleukin (IL)-12 and inhibit the expression of Toll-like receptor 4 (TLR4) and chemokine (C-X-C motif) receptor 3 (CXCR3), which means asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival.
TargetsIL Receptor | IFN-γ | CXCR | TLR
In vitro

Experimental study of the effects of Asarinin on immunosuppression activity in vitro.[Reference: WebLink]

Chinese Journal of Cardiology, 2003, 31(6):444-7.

To test the extract of Asarum heterotropides called Asarinin in the immunosuppression activity in vitro and compared with cyclosporine A(CsA).
METHODS AND RESULTS:
Cardiomyocytes of adult wistar rats and spleen cells of adult SD rats were separated. 0.1 ml of the cardiomyocytes(2×10~(6)/ml) as stimulate cells and 0.1 ml of spleen cells(1×10~(7)/ml) as response cells were cultured in 96 culture plates. The model of rejection reaction in vitro was set up. Then the 0.1 ml serum including Asarinin was given to culture plates, the inhibition rate of lymphocyte transformation was investigated with MTT after 108 hours and IL-2、INF-#gamma#、IL-4 were detected with ELISA. Asarinin inhibited the lymphocyte transformation (inhibition rate 60.37%) in vitro.
CONCLUSIONS:
Compared with positive control group, it significantly decreased IL-2(69.11±17.47 pg/ml vs 160.44±19.79 pg/ ml, P<0.01)、INF-#gamma#(183.11± 95.24 pg/ml vs 521.89± 133.18 pg/ml, P<0.01) and increased IL-4(53.14±11.80 pg/ml vs 14.44± 4.21 pg/ml, P<0.01)in culture plates.

In vivo

The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation.[Pubmed: 25769604]

Transplant Proc. 2015 Mar;47(2):545-8.

The objective of this study was to study the mechanism of the anti-rejection effect of Asarinin in rats that underwent cardiac allograft implantation.
METHODS AND RESULTS:
Hearts from Wistar rats were transplanted into the abdominal cavity of Sprague Dawley rats (SD rats) 64 SD rats received either cyclosporin A (CsA), Asarinin, or demi-dose of cyclosporine A and Asarinin through oral administration. On the seventh day post-transplantation, the expression of Toll-like receptor 4 (TLR4), chemokine (C-X-C motif) receptor 3 (CXCR3) in myocardium, and the level of interleukin (IL)-12 in the peripheral blood were analyzed 7 days after transplantation. The survival time in 3 groups (CsA group, Asarinin group, and semi-dose CsA group) prolonged (P < .01), the microscope myocardial histopathology in 3 groups (CsA group, Asarinin group and semi-dose CsA group) relieved, the expression of TLR4 and CXCR3 in 3 groups was significantly decreased (P < .01) when compared with the control group. The level of IL-12 decreased remarkably (P < .05) in the 3 groups when compared with the control group.
CONCLUSIONS:
The combined data suggested that Asarinin decreased peripheral blood concentration of IL-12 and inhibited the expression of TLR4 and CXCR3, which means Asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival.

Protocol of (-)-Asarinin

Kinase Assay

Inhibition of Δ5-desaturase in polyunsaturated fatty acid biosynthesis by (−)-asarinin and (−)-epiasarinin.[Reference: WebLink]

Phytochemistry, 1992, 31(3):757-60.


METHODS AND RESULTS:
An extract of Chinese medicine, saishin (Asiasari radix), was found to increase the mycelial dihomo-γ-linolenic acid content of an arachidonic acid-producing fungus, Mortierelia alpina, with an accompanying decrease in its arachidonic acid content. The factors responsible for this phenomenon were isolated and identified as (−)-asarinin and (−)-epiasarinin, which are the enantiomers of (+)-episesamin and (+)-sesamin, respectively. The inhibitory effects on the Δ5-desaturase in rat liver microsomes of these factors were in the order of (+)-sesamin > (−)-epiasarinin > (−)-asarinin > (+)-episesamin.
CONCLUSIONS:
Kinetic analysis showed that (−)-asarinin and (−)-epiasarinin are non-competitive inhibitors, the Kis for rat liver Δ5-desaturase being 2.8 × 10−4 and 7.1 × 10−4 M, respectively, which are almost the same as the values of the (+)-enantiomers.

Structure Identification
Acta Crystallogr C. 2013 Jan;69(Pt 1):87-9.

(±)-Asarinin.[Pubmed: 23282922]

Asarinin, C(20)H(18)O(6), was isolated as a racemate from the shrub Zanthoxylum alatum.
METHODS AND RESULTS:
Both forms of the enantiomerically pure substance, (+)- and (-)-Asarinin, have been the subject of a total of five previous structure determinations that are essentially identical except for the absolute stereochemistry. However, there seems to be some confusion in the literature concerning these structure determinations of asarinin and also those of its stereoisomer sesamin. The molecular structure of racemic asarinin differs from that of the pure enantiomers in the orientation of one ring system.
CONCLUSIONS:
In the packing of the racemate, molecules are linked by C-H...O interactions to form ribbons parallel to [101].

Food Chem., 2011, 124(3):895-9.

A new mammalian lignan precursor, asarinin.[Reference: WebLink]

Enterolactone (ENL) and enterodiol are mammalian lignans.
METHODS AND RESULTS:
Several plant lignans have been reported as precursors of mammalian lignans. However, asarinin (AS), a furofuran type lignan which occurs in medicinal plants and foods, has not been reported as mammalian lignan precursor to date. After the incubation of AS with human intestinal microflora, AS was converted to not only ENL, but also two more metabolites (mono-demethylenated and ring-cleaved compounds). Under the same conditions, sesamin (SM) was converted to ENL. Furthermore, chiral HPLC analysis showed that ENL produced from AS and SM was (−)-ENL.
CONCLUSIONS:
This is the first report which shows that AS is a mammalian lignan precursor.

(-)-Asarinin Dilution Calculator

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(-)-Asarinin Molarity Calculator

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Preparing Stock Solutions of (-)-Asarinin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8221 mL 14.1103 mL 28.2207 mL 56.4414 mL 70.5517 mL
5 mM 0.5644 mL 2.8221 mL 5.6441 mL 11.2883 mL 14.1103 mL
10 mM 0.2822 mL 1.411 mL 2.8221 mL 5.6441 mL 7.0552 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.1288 mL 1.411 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (-)-Asarinin

The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation.[Pubmed:25769604]

Transplant Proc. 2015 Mar;47(2):545-8.

OBJECTIVE: The objective of this study was to study the mechanism of the anti-rejection effect of Asarinin in rats that underwent cardiac allograft implantation. METHODS: Hearts from Wistar rats were transplanted into the abdominal cavity of Sprague Dawley rats (SD rats) 64 SD rats received either cyclosporin A (CsA), Asarinin, or demi-dose of cyclosporine A and Asarinin through oral administration. On the seventh day post-transplantation, the expression of Toll-like receptor 4 (TLR4), chemokine (C-X-C motif) receptor 3 (CXCR3) in myocardium, and the level of interleukin (IL)-12 in the peripheral blood were analyzed 7 days after transplantation. RESULTS: The survival time in 3 groups (CsA group, Asarinin group, and semi-dose CsA group) prolonged (P < .01), the microscope myocardial histopathology in 3 groups (CsA group, Asarinin group and semi-dose CsA group) relieved, the expression of TLR4 and CXCR3 in 3 groups was significantly decreased (P < .01) when compared with the control group. The level of IL-12 decreased remarkably (P < .05) in the 3 groups when compared with the control group. CONCLUSIONS: The combined data suggested that Asarinin decreased peripheral blood concentration of IL-12 and inhibited the expression of TLR4 and CXCR3, which means Asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival.

(+/-)-Asarinin.[Pubmed:23282922]

Acta Crystallogr C. 2013 Jan;69(Pt 1):87-9.

Asarinin, C(20)H(18)O(6), was isolated as a racemate from the shrub Zanthoxylum alatum. Both forms of the enantiomerically pure substance, (+)- and (-)-Asarinin, have been the subject of a total of five previous structure determinations that are essentially identical except for the absolute stereochemistry. However, there seems to be some confusion in the literature concerning these structure determinations of asarinin and also those of its stereoisomer sesamin. The molecular structure of racemic asarinin differs from that of the pure enantiomers in the orientation of one ring system. In the packing of the racemate, molecules are linked by C-H...O interactions to form ribbons parallel to [101].

Description

(-)-Asarinin is a extract lignan from Zanthoxylum armatum, mainly produced in roots of this herb[1].

Keywords:

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