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Benzoylpaeoniflorin

CAS# 38642-49-8

Benzoylpaeoniflorin

Catalog No. BCN6293----Order now to get a substantial discount!

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Benzoylpaeoniflorin: 5mg $35 In Stock
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Quality Control of Benzoylpaeoniflorin

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Chemical structure

Benzoylpaeoniflorin

3D structure

Chemical Properties of Benzoylpaeoniflorin

Cas No. 38642-49-8 SDF Download SDF
PubChem ID 170087 Appearance White cryst.
Formula C30H32O12 M.Wt 584.57
Type of Compound Monoterpenoids Storage Desiccate at -20°C
Solubility DMSO : ≥ 34 mg/mL (58.16 mM)
*"≥" means soluble, but saturation unknown.
SMILES CC12CC(C(C1O)O)(OC2(COC(=O)C3=CC=CC=C3)OC45CC6=COC(=C64)OC5)COC(=O)C7CC(C(C=C7)O)O
Standard InChIKey KHRHASRIMPQOPU-PAMKKNMFSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Benzoylpaeoniflorin

The root of Paeonia lactiflora Pall.

Biological Activity of Benzoylpaeoniflorin

DescriptionBenzoylpaeoniflorin is active against cyclooxygenase(COX)-1 and COX-2 enzymes, it can restrain apoptosis of rats with coronary heart diseases by increasing the levels of Bc1-2 and decreasing the levels of Bax.
TargetsBcl-2/Bax | COX
In vivo

Effects of Benzoylpaeoniflorin on apoptosis of Rats with Coronary Heart Diseases.[Reference: WebLink]

Chinese Journal of Laboratory Diagnosis, 2011, 15(4): 609-10.

To Study the effects of Benzoylpaeoniflorin on apoptosis of rats with coronary heart diseases.
METHODS AND RESULTS:
Experimental rats model with coronary heart diseases caused by high fat foods were prepared and Benzoylpaeoniflorin were given for 4 weeks.Bc1-2、Bax in cardiac muscles of rats were detected with immunohistochemistry. Compared with that in normal group,Bc1-2 is lower and Bax is higher in model group(P0.05);After treatment,Bc1-2 increased and Bax decreased in treatment group.There is significant difference about Bc1-2 and Bax in treatment group and in model group(P0.05).But there is no great difference between treatment group and normal group(P0.05).
CONCLUSIONS:
Benzoylpaeoniflorin can restrain apoptosis of rats with coronary heart diseases by increasing the levels of Bc1-2 and decreasing the levels of Bax,suggesting that Benzoylpaeoniflorin may treat coronary heart disease by decreasing apoptosis.

Protocol of Benzoylpaeoniflorin

Kinase Assay

New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.[Pubmed: 24236670]

Nat Prod Res. 2014;28(5):301-5.


METHODS AND RESULTS:
The methanol extract of the root cortex of Paeonia suffruticosa afforded two new monoterpene glycosides, paeoniside A (1) and paeoniside B (2), and three known monoterpene glycosides, paeoniflorin (3), Benzoylpaeoniflorin (4) and 4-O-methyl-paeoniflorin (5). Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments.
CONCLUSIONS:
Compounds 1-5 were found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.

Structure Identification
J Pharm Biomed Anal. 2014 Sep;98:424-33.

Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatograph[Pubmed: 25011060]


METHODS AND RESULTS:
In this study, a improved high performance liquid chromatography-diode array detector (HPLC-DAD) method for simultaneous quantification of twelve major components belonging to three chemical types was developed and validated, and was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fumigated with different durations and purchased from commercial herbal markets. The contents of paeoniflorin, Benzoylpaeoniflorin, oxypaeoniflorin, benzoic acid and paeonol decreased whereas that of paeoniflorin sulfonate increased in RPA with the extending of sulfur-fumigation duration. Different levels of paeoniflorin sulfonate were determined in ten of seventeen commercial RPA samples, indicating that these ten samples may be sulfur-fumigated with different durations. Moreover, the relative standard deviation of the contents of each component was higher in the commercial sulfur-fumigated RPA samples than that in commercial non-fumigated RPA samples, and the percentage of the total average content of monoterpene glycosides in the determined analytes was higher in the decoctions of commercial sulfur-fumigated RPA than that in commercial non-fumigated RPA samples.
CONCLUSIONS:
All these results suggested that the established method was precise, accurate and sensitive enough for the global quality evaluation of sulfur-fumigated RPA, and sulfur-fumigation can not only change the proportions of bioactive components, but also cause the reduction of the quality consistency of both raw materials and aqueous decoctions of RPA.

Benzoylpaeoniflorin Dilution Calculator

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Preparing Stock Solutions of Benzoylpaeoniflorin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7107 mL 8.5533 mL 17.1066 mL 34.2132 mL 42.7665 mL
5 mM 0.3421 mL 1.7107 mL 3.4213 mL 6.8426 mL 8.5533 mL
10 mM 0.1711 mL 0.8553 mL 1.7107 mL 3.4213 mL 4.2766 mL
50 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.6843 mL 0.8553 mL
100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.3421 mL 0.4277 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Benzoylpaeoniflorin

Benzoylpaeoniflorin is a natural product; may treat coronary heart disease by decreasing apoptosis.

References:
[1]. Xinfeng Zhao, et al. Quantitative and Qualitative Determination of Liuwei Dihuang Tablets by HPLC–UV-MS–MS. Journal of Chromatographic Science, Vol. 45, September 2007, 549-552 [2]. ZHANG Er-li, et al. Effects of Benzoylpaeoniflorin on apoptosis of Rats with Coronary Heart Diseases. Chinese Journal of Laboratory Diagnosis, 2011-04.

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References on Benzoylpaeoniflorin

Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines.[Pubmed:25431610]

Evid Based Complement Alternat Med. 2014;2014:521038.

A simple and sensitive HPLC-DAD detection method was established for the simultaneous determination of nine compounds including oxypaeoniflorin, albiflorin, paeoniflorin, Benzoylpaeoniflorin, glycyrrhizic acid, liquiritin, isoliquiritin, liquiritigenin, and isoliquiritigenin in the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang (SGT) and we analyze the relationship between therapeutical effect and compatibility of medicines by using an Agilent extend-C18 column at a flow rate of 1 mL/min. The column temperature was maintained at 30 degrees C and the detection wavelength was set at 230 nm for oxypaeoniflorin, albiflorin, paeoniflorin, Benzoylpaeoniflorin, and glycyrrhizic acid; 276 nm for liquiritin and liquiritigenin; 360 nm for isoliquiritin and isoliquiritigenin. The total contents of the nine compounds in SGT varied from 4.65 to 20.06 mg/mL. The results of this study showed that the content of chemical compounds of Traditional Chinese Medicinal Prescription is mainly influenced by the dosage and compatibility of medicines and the therapeutical effect of Traditional Chinese Medicinal prescription is mainly influenced by the dosage and compatibility of medicines. The method could be suitable for quality control of SGT with bioactive multicompounds.

New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.[Pubmed:24236670]

Nat Prod Res. 2014;28(5):301-5.

The methanol extract of the root cortex of Paeonia suffruticosa afforded two new monoterpene glycosides, paeoniside A (1) and paeoniside B (2), and three known monoterpene glycosides, paeoniflorin (3), Benzoylpaeoniflorin (4) and 4-O-methyl-paeoniflorin (5). Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments. Compounds 1-5 were found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.

Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatography-diode array detector.[Pubmed:25011060]

J Pharm Biomed Anal. 2014 Sep;98:424-33.

In this study, a improved high performance liquid chromatography-diode array detector (HPLC-DAD) method for simultaneous quantification of twelve major components belonging to three chemical types was developed and validated, and was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fumigated with different durations and purchased from commercial herbal markets. The contents of paeoniflorin, Benzoylpaeoniflorin, oxypaeoniflorin, benzoic acid and paeonol decreased whereas that of paeoniflorin sulfonate increased in RPA with the extending of sulfur-fumigation duration. Different levels of paeoniflorin sulfonate were determined in ten of seventeen commercial RPA samples, indicating that these ten samples may be sulfur-fumigated with different durations. Moreover, the relative standard deviation of the contents of each component was higher in the commercial sulfur-fumigated RPA samples than that in commercial non-fumigated RPA samples, and the percentage of the total average content of monoterpene glycosides in the determined analytes was higher in the decoctions of commercial sulfur-fumigated RPA than that in commercial non-fumigated RPA samples. All these results suggested that the established method was precise, accurate and sensitive enough for the global quality evaluation of sulfur-fumigated RPA, and sulfur-fumigation can not only change the proportions of bioactive components, but also cause the reduction of the quality consistency of both raw materials and aqueous decoctions of RPA.

Description

Benzoylpaeoniflorin is a natural product; may treat coronary heart disease by decreasing apoptosis.

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