Besifloxacin HCl

CAS# 405165-61-9

Besifloxacin HCl

Catalog No. BCC4764----Order now to get a substantial discount!

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Besifloxacin HCl: 5mg $46 In Stock
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Quality Control of Besifloxacin HCl

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Chemical structure

Besifloxacin HCl

3D structure

Chemical Properties of Besifloxacin HCl

Cas No. 405165-61-9 SDF Download SDF
PubChem ID 10224595 Appearance Powder
Formula C19H22Cl2FN3O3 M.Wt 430.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility H2O : < 0.1 mg/mL (insoluble)
Chemical Name 7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid;hydrochloride
SMILES C1CCN(CC(C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F.Cl
Standard InChIKey PMQBICKXAAKXAY-HNCPQSOCSA-N
Standard InChI InChI=1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H/t10-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Besifloxacin HCl

DescriptionBesifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic. IC50 Value: Target: Antibacterial Besifloxacin has been found to inhibit production of pro-inflammatory cytokines in vitro. Besifloxacin is a novel 8-chloro-fluoroquinolone agent with potent, bactericidal activity against prevalent and drug-resistant pathogens.besifloxacin is the most potent agent tested against gram-positive pathogens and anaerobes and is generally equivalent to comparator fluoroquinolones in activity against most gram-negative pathogens. Besifloxacin demonstrates potent, broad-spectrum activity, which is particularly notable against gram-positive and gram-negative isolates that are resistant to other fluoroquinolones and classes of antibacterial agents.

References:
[1]. Wang Z, Wang S, Zhu F, Chen Z, Yu L, Zeng S. Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization. Chirality. 2012 Jul;24(7):526-31. doi: 10.1002/chir.22042. [2]. Hussar DA. New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine. J Am Pharm Assoc (2003). 2009 Jul-Aug;49(4):570-4. [3]. Nafziger AN, Bertino JS Jr. Besifloxacin ophthalmic suspension for bacterial conjunctivitis. Drugs Today (Barc). 2009 Aug;45(8):577-88. [4]. Proksch JW, Ward KW. Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits. J Ocul Pharmacol Ther. 2010 Oct;26(5):449-58. [5]. Comstock TL, Paterno MR, Usner DW, Pichichero ME. Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group,

Besifloxacin HCl Dilution Calculator

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Besifloxacin HCl Molarity Calculator

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Preparing Stock Solutions of Besifloxacin HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.324 mL 11.6198 mL 23.2396 mL 46.4792 mL 58.099 mL
5 mM 0.4648 mL 2.324 mL 4.6479 mL 9.2958 mL 11.6198 mL
10 mM 0.2324 mL 1.162 mL 2.324 mL 4.6479 mL 5.8099 mL
50 mM 0.0465 mL 0.2324 mL 0.4648 mL 0.9296 mL 1.162 mL
100 mM 0.0232 mL 0.1162 mL 0.2324 mL 0.4648 mL 0.581 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Besifloxacin HCl

Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic.

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Description

Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic.

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