Chlorahololide C

CAS# 1007859-25-7

Chlorahololide C

Catalog No. BCN7256----Order now to get a substantial discount!

Product Name & Size Price Stock
Chlorahololide C: 5mg $1064 In Stock
Chlorahololide C: 10mg Please Inquire In Stock
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Chlorahololide C: 500mg Please Inquire Please Inquire
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Quality Control of Chlorahololide C

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Chemical structure

Chlorahololide C

3D structure

Chemical Properties of Chlorahololide C

Cas No. 1007859-25-7 SDF Download SDF
PubChem ID 127045345 Appearance Powder
Formula C33H36O9 M.Wt 576.64
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2C(C3C(=C)C4CC4C3(C5C2(C6=C7C(C8CC8C7(C5)O)(C(C(=O)C6=C(C)C(=O)OC)O)C)OC1=O)C)OC(=O)C
Standard InChIKey FUWHPWXSVUDXDS-XMJAEXKHSA-N
Standard InChI InChI=1S/C33H36O9/c1-11-15-8-16(15)30(5)19-10-32(39)18-9-17(18)31(6)26(32)23(20(24(35)27(31)36)12(2)28(37)40-7)33(19)22(13(3)29(38)42-33)25(21(11)30)41-14(4)34/h15-19,21,25,27,36,39H,1,8-10H2,2-7H3/b20-12-/t15-,16-,17-,18+,19+,21-,25-,27+,30-,31+,32+,33-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chlorahololide C

The whole plants of Chloranthus holostegius.

Biological Activity of Chlorahololide C

Description1. Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M.
TargetsPotassium Channel

Chlorahololide C Dilution Calculator

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Chlorahololide C Molarity Calculator

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Preparing Stock Solutions of Chlorahololide C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7342 mL 8.6709 mL 17.3418 mL 34.6837 mL 43.3546 mL
5 mM 0.3468 mL 1.7342 mL 3.4684 mL 6.9367 mL 8.6709 mL
10 mM 0.1734 mL 0.8671 mL 1.7342 mL 3.4684 mL 4.3355 mL
50 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.6937 mL 0.8671 mL
100 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.3468 mL 0.4335 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chlorahololide C

Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius

Tetrahedron, 2008, 64(9):2027-2034.

Four unusually fused polycyclic sesquiterpenoid dimers, Chlorahololide C,chlorahololide D, chlorahololide E, chlorahololide F (1 - 4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C - F (1 - 4) exerted potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) values of 3.6 +/- 10.1, 2.7 +/- 0.3, 27.5 +/- 5.1. and 57.5 +/- 6.1 mu M, respectively.

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