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Coronarin D methyl ether

CAS# 157528-81-9

Coronarin D methyl ether

Catalog No. BCN1705----Order now to get a substantial discount!

Product Name & Size Price Stock
Coronarin D methyl ether: 5mg $690 In Stock
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Quality Control of Coronarin D methyl ether

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Chemical structure

Coronarin D methyl ether

3D structure

Chemical Properties of Coronarin D methyl ether

Cas No. 157528-81-9 SDF Download SDF
PubChem ID 102004387 Appearance Powder
Formula C21H32O3 M.Wt 332.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3E)-3-[2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-methoxyoxolan-2-one
SMILES CC1(CCCC2(C1CCC(=C)C2CC=C3CC(OC3=O)OC)C)C
Standard InChIKey AXVHMYNDGVQIQD-CDRZHGAUSA-N
Standard InChI InChI=1S/C21H32O3/c1-14-7-10-17-20(2,3)11-6-12-21(17,4)16(14)9-8-15-13-18(23-5)24-19(15)22/h8,16-18H,1,6-7,9-13H2,2-5H3/b15-8+/t16-,17-,18?,21+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Coronarin D methyl ether

The rhizomes of Hedychium coronarium

Biological Activity of Coronarin D methyl ether

Description1. Coronarin D methyl ether has inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction.
TargetsTNF-α | IL Receptor

Coronarin D methyl ether Dilution Calculator

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Coronarin D methyl ether Molarity Calculator

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Preparing Stock Solutions of Coronarin D methyl ether

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0075 mL 15.0376 mL 30.0752 mL 60.1504 mL 75.188 mL
5 mM 0.6015 mL 3.0075 mL 6.015 mL 12.0301 mL 15.0376 mL
10 mM 0.3008 mL 1.5038 mL 3.0075 mL 6.015 mL 7.5188 mL
50 mM 0.0602 mL 0.3008 mL 0.6015 mL 1.203 mL 1.5038 mL
100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6015 mL 0.7519 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Coronarin D methyl ether

Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed:22071304]

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5.

The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, Coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, beta-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-alpha, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19+/-0.11 to 10.38+/-2.34 muM. The remains of compounds showed inactivity or due to cytotoxicity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.

Labdane diterpenes from the rhizomes of Hedychium coronarium.[Pubmed:18932088]

Nat Prod Res. 2008;22(14):1249-56.

A new labdane diterpenoid, (E)-labda-8(17),12-dien-15,16-olide (1) together with eight known compounds, coronarin D (2), Coronarin D methyl ether (3), coronarin D ethyl ether (4), isocoronarin D (5), coronarin B (6), labda-8(17),11,13-trien-15,16-olide (7), (E)-labda-8(17),12-diene-15,16-dial (8) and 16-hydroxylabda-8(17),11,13-trien-15,16-olide (9), are isolated from the rhizomes of Hedychium coronarium. Compounds 2-4, 5 and 9 are isolated as mixtures of C-15, C-14 and C-16 epimers, respectively. Their structures are determined on the basis of their spectroscopic data. The epimeric mixtures of 2 and 3 have not been reported before. Some of them were evaluated for their cytotoxicity.

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