Coulteropine

CAS# 6014-62-6

Coulteropine

Catalog No. BCN7420----Order now to get a substantial discount!

Product Name & Size Price Stock
Coulteropine: 5mg $690 In Stock
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Quality Control of Coulteropine

Number of papers citing our products

Chemical structure

Coulteropine

3D structure

Chemical Properties of Coulteropine

Cas No. 6014-62-6 SDF Download SDF
PubChem ID 371260 Appearance Powder
Formula C21H21NO6 M.Wt 383.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CCC2=CC3=C(C(=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OC)OCO3
Standard InChIKey SWBXJEKOHMOEFV-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H21NO6/c1-22-6-5-13-8-17-20(28-11-26-17)21(24-2)18(13)15(23)7-12-3-4-16-19(14(12)9-22)27-10-25-16/h3-4,8H,5-7,9-11H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Coulteropine

The aerial parts of Papaver rhoeas L.

Biological Activity of Coulteropine

DescriptionCoulteropine is a natural product from Papaver rhoeas L.

Protocol of Coulteropine

Structure Identification
Pharm Biol. 2017 Dec;55(1):1894-1898.

Variation of alkaloid contents and antimicrobial activities of Papaver rhoeas L. growing in Turkey and northern Cyprus.[Pubmed: 28633584 ]

From the aerial parts of P. rhoeas samples, alkaloids were isolated by column and preparative thin-layer chromatography.
METHODS AND RESULTS:
The alkaloids were identified by comparing their spectral data (UV, IR and 1H-NMR) and TLC Rf values with those of authentic samples. The antimicrobial study was carried out by microbroth dilution technique against six strains of bacteria and three strains of fungi. RESULTS: Twelve different alkaloids belonging to proaporphine (mecambrine), aporphine (roemerine), promorphinan (salutaridine), protopine (Coulteropine and protopine) and rhoeadine (epiglaucamine, glaucamine, glaudine, isorhoeadine, isorhoeagenine, rhoeadine and rhoeagenine) groups were isolated. The most significant activity was observed with the alkaloid extract of P8 against Staphylococcus aureus with a MIC value of 1.22 μg/mL and against Candida albicans with a MIC value of 2.4 μg/mL.
CONCLUSIONS:
The results indicate that P. rhoeas samples (P8 and P9), which contain roemerine as their major alkaloid, were the most active extracts.

Coulteropine Dilution Calculator

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Coulteropine Molarity Calculator

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Preparing Stock Solutions of Coulteropine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6082 mL 13.0412 mL 26.0824 mL 52.1648 mL 65.2061 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL 10.433 mL 13.0412 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL 5.2165 mL 6.5206 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.0433 mL 1.3041 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.6521 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Coulteropine

Variation of alkaloid contents and antimicrobial activities of Papaver rhoeas L. growing in Turkey and northern Cyprus.[Pubmed:28633584]

Pharm Biol. 2017 Dec;55(1):1894-1898.

CONTEXT: Papaver rhoeas L. (Papaveraceae) corn poppy, widely distributed in Turkey, is used to make a cough syrup for children, as a tea for disturbed sleep, for pain relief and as a sedative in folk medicine. OBJECTIVE: Samples of P. rhoeas collected from eight different locations in Turkey and three from northern Cyprus were investigated for their alkaloid content and screened for their antimicrobial activities. MATERIALS AND METHODS: From the aerial parts of P. rhoeas samples, alkaloids were isolated by column and preparative thin-layer chromatography. The alkaloids were identified by comparing their spectral data (UV, IR and (1)H-NMR) and TLC Rf values with those of authentic samples. The antimicrobial study was carried out by microbroth dilution technique against six strains of bacteria and three strains of fungi. RESULTS: Twelve different alkaloids belonging to proaporphine (mecambrine), aporphine (roemerine), promorphinan (salutaridine), protopine (Coulteropine and protopine) and rhoeadine (epiglaucamine, glaucamine, glaudine, isorhoeadine, isorhoeagenine, rhoeadine and rhoeagenine) groups were isolated. The most significant activity was observed with the alkaloid extract of P8 against Staphylococcus aureus with a MIC value of 1.22 mug/mL and against Candida albicans with a MIC value of 2.4 mug/mL. DISCUSSION: The results indicate that P. rhoeas samples (P8 and P9), which contain roemerine as their major alkaloid, were the most active extracts.

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