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Sodium 4-Aminosalicylate

CAS# 6018-19-5

Sodium 4-Aminosalicylate

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Sodium 4-Aminosalicylate: 5mg $12 In Stock
Sodium 4-Aminosalicylate: 10mg Please Inquire In Stock
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Chemical structure

Sodium 4-Aminosalicylate

3D structure

Chemical Properties of Sodium 4-Aminosalicylate

Cas No. 6018-19-5 SDF Download SDF
PubChem ID 16211148 Appearance Powder
Formula C7H10NNaO5 M.Wt 211.15
Type of Compound N/A Storage Desiccate at -20°C
Synonyms 4-Amino-salicylic acid sodium salt
Solubility H2O : ≥ 49 mg/mL (232.06 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name sodium;4-amino-2-hydroxybenzoate;dihydrate
SMILES C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
Standard InChIKey GMUQJDAYXZXBOT-UHFFFAOYSA-M
Standard InChI InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Sodium 4-Aminosalicylate

DescriptionSodium 4-aminosalicylate dihydrate is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.

References:
[1]. Zheng J, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 9;288(32):23447-56. [2]. Sy SK, et al. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in drug-resistant pulmonary tuberculosis patients. Antimicrob Agents Chemother. 2015 May 11. pii: AAC.04049-14.

Sodium 4-Aminosalicylate Dilution Calculator

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Sodium 4-Aminosalicylate Molarity Calculator

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Preparing Stock Solutions of Sodium 4-Aminosalicylate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.736 mL 23.6798 mL 47.3597 mL 94.7194 mL 118.3992 mL
5 mM 0.9472 mL 4.736 mL 9.4719 mL 18.9439 mL 23.6798 mL
10 mM 0.4736 mL 2.368 mL 4.736 mL 9.4719 mL 11.8399 mL
50 mM 0.0947 mL 0.4736 mL 0.9472 mL 1.8944 mL 2.368 mL
100 mM 0.0474 mL 0.2368 mL 0.4736 mL 0.9472 mL 1.184 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.

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Description

Sodium 4-aminosalicylate dihydrate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.

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