EO 1428

CAS# 321351-00-2

EO 1428

Catalog No. BCC7511----Order now to get a substantial discount!

Product Name & Size Price Stock
EO 1428: 5mg $127 In Stock
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Chemical structure

EO 1428

3D structure

Chemical Properties of EO 1428

Cas No. 321351-00-2 SDF Download SDF
PubChem ID 9801969 Appearance Powder
Formula C20H16BrClN2O M.Wt 415.71
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
Chemical Name [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone
SMILES CC1=CC=CC=C1C(=O)C2=C(C=C(C=C2)NC3=C(C=C(C=C3)Br)N)Cl
Standard InChIKey HDCLCHNAEZNGNV-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of EO 1428

DescriptionSelective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

EO 1428 Dilution Calculator

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EO 1428 Molarity Calculator

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Preparing Stock Solutions of EO 1428

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4055 mL 12.0276 mL 24.0552 mL 48.1105 mL 60.1381 mL
5 mM 0.4811 mL 2.4055 mL 4.811 mL 9.6221 mL 12.0276 mL
10 mM 0.2406 mL 1.2028 mL 2.4055 mL 4.811 mL 6.0138 mL
50 mM 0.0481 mL 0.2406 mL 0.4811 mL 0.9622 mL 1.2028 mL
100 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.4811 mL 0.6014 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on EO 1428

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.[Pubmed:14667219]

J Med Chem. 2003 Dec 18;46(26):5651-62.

We wish to report the synthesis and structure-activity relationship (SAR) of a series of 4-aminobenzophenones, as a novel compound class with high antiinflammatory activity. Our initial lead, (4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone (3), was systematically optimized and resulted in compounds that potently inhibited the release of the proinflammatory cytokines IL-1beta and TNF-alpha in human peripheral blood mononuclear cells stimulated by LPS. One of the most potent compounds, among others, was (4-[(2-aminophenyl)amino]-2-chlorophenyl)(2-methylphenyl)methanone (45) with IC(50) values of 14 and 6 nM for the inhibition of IL-1beta and TNF-alpha, respectively. Furthermore, we found these types of compounds to be potent and selective p38 MAP kinase inhibitors, e.g. 45 had an IC(50) value of 10 nM. Molecular modeling was used to rationalize our SAR data and to propose a model for the interaction of compound 45 with the p38 MAP kinase. The model involved a favorable hydrogen bond between the carbonyl group of the benzophenone and the NH of Met-109, positioning ring A in the hydrophobic pocket I of the enzyme. Good antiinflammatory effects were demonstrated in two murine models of dermatitis after topical application (oxazolone and TPA model).

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