Echinatin

CAS# 34221-41-5

Echinatin

Catalog No. BCN6277----Order now to get a substantial discount!

Product Name & Size Price Stock
Echinatin: 5mg $81 In Stock
Echinatin: 10mg Please Inquire In Stock
Echinatin: 20mg Please Inquire Please Inquire
Echinatin: 50mg Please Inquire Please Inquire
Echinatin: 100mg Please Inquire Please Inquire
Echinatin: 200mg Please Inquire Please Inquire
Echinatin: 500mg Please Inquire Please Inquire
Echinatin: 1000mg Please Inquire Please Inquire

Quality Control of Echinatin

Number of papers citing our products

Chemical structure

Echinatin

3D structure

Chemical Properties of Echinatin

Cas No. 34221-41-5 SDF Download SDF
PubChem ID 6442675 Appearance Orange powder
Formula C16H14O4 M.Wt 270.28
Type of Compound Chalcones Storage Desiccate at -20°C
Synonyms 4,4'-Dihydroxy 2-methoxychalcone; Retrochalcone
Solubility DMSO : 250 mg/mL (924.97 mM; Need ultrasonic)
Chemical Name (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
SMILES COC1=C(C=CC(=C1)O)C=CC(=O)C2=CC=C(C=C2)O
Standard InChIKey QJKMIJNRNRLQSS-WEVVVXLNSA-N
Standard InChI InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Echinatin

1 Glycyrrhiza sp.

Biological Activity of Echinatin

DescriptionEchinatin has significant antioxidant and anti-inflammary activities, it shows strong scavenging activity toward the ABTS + radical, it also inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Echinatin disturbs the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity.
TargetsATPase | ROS | NO | PGE | IL Receptor
In vitro

The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.[Pubmed: 6221118]

J Toxicol Sci. 1982 Nov;7(4):245-54.


METHODS AND RESULTS:
To investigate the mechanism by which various biological action of licorice root are brought about, the effects of Echinatin as a small constituent of Glycyrrhiza echinata and several related compounds on mitochondrial energy transfer reactions were examined. The results obtained were as follows: 1) Echinatin, 4'-hydroxychalcone, chalcone and 3,4'-dihydroxychalcone at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria. 2) Chalcone and 4'-hydroxychalcone stimulate both latent and DNP-ATPase activity of mitochondria. Echinatin inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. 3) Chalcone and 4'-hydroxychalcone induce a rapid potassium release from mitochondrial vesicles, while Echinatin and 3,4'-dihydroxychalcone have lesser effect than the former two substances.
CONCLUSIONS:
From these results, it can be concluded that Echinatin and several related compounds disturb the mitochondrial energy transfer reactions and membrane permeability.

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.[Pubmed: 23790887]

Food Chem. 2013 Nov 15;141(2):1063-71.

Licorice, the roots and rhizomes of several Glycyrrhiza species (Leguminosae), is an important natural sweetening agent and a widely used herbal medicine.
METHODS AND RESULTS:
In this work, six flavonoids, 5-(1,1-dimethylallyl)-3,4,4'-trihydroxy-2-methoxychalcone (1), licochalcone B (2), licochalcone A (3), Echinatin (4), glycycoumarin (5) and glyurallin B (6), were isolated from the extracts of licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Their structures were elucidated using various spectroscopic methods. To our knowledge, compound 1 was isolated from natural plants for the first time. All the isolates were tested by antioxidant and anti-inflammatory assays. Compounds 2, 4 and 5 showed strong scavenging activity toward the ABTS(+) radical, and compounds 1, 2, 3, 5 and 6 exhibited potent inhibition of lipid peroxidation in rat liver microsomes compared with the reference controls. Compounds 1-4 dose-dependently inhibited LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells. Furthermore, compounds 1-5 were demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Moreover, the contents of the six compounds, in different Glycyrrhiza species, were quantified by HPLC-MS.

Determination of antioxidant activity in licorice vitro metabolites by DPPH spiking coupled with HPLC-Q-TOF MS/MS[Reference: WebLink]

Chinese Journal of New Drugs, 2013, 22(21):2547-52.

To investigate the antioxidant activity of liver microsomal metabolites from six flavonoids in licorice by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) spiking coupled with HPLC-Q-TOF MS/MS.
METHODS AND RESULTS:
The six flavonoids were incubated with rat liver microsomes and the resultant metabolites were identified by HPLC-Q-TOF MS/MS. The antioxidant activity of the metabolites was calculated by comparing the peak area changes before and after incubation with DPPH. The peak area of the metabolites significantly decreased or even disappeared after incubation with DPPH. Besides the metabolites Lico A-M1 and Lico A-M2 of licochalcone A, more than 90% of other metabolites of flavonoids were oxidized.
CONCLUSIONS:
Liver microsomal metabolites of Echinatin, licochalcone B, licochalcone A, 5-(1, 1-dimethylally)-3, 4, 4'-trihydroxy-2-methoxychalcone, glycycourmarin and glyurallin B still have significant antioxidant activities.

Echinatin Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Echinatin Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Echinatin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL 73.9973 mL 92.4967 mL
5 mM 0.74 mL 3.6999 mL 7.3997 mL 14.7995 mL 18.4993 mL
10 mM 0.37 mL 1.8499 mL 3.6999 mL 7.3997 mL 9.2497 mL
50 mM 0.074 mL 0.37 mL 0.74 mL 1.4799 mL 1.8499 mL
100 mM 0.037 mL 0.185 mL 0.37 mL 0.74 mL 0.925 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Echinatin

The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.[Pubmed:6221118]

J Toxicol Sci. 1982 Nov;7(4):245-54.

To investigate the mechanism by which various biological action of licorice root are brought about, the effects of Echinatin as a small constituent of Glycyrrhiza echinata and several related compounds on mitochondrial energy transfer reactions were examined. The results obtained were as follows: 1) Echinatin, 4'-hydroxychalcone, chalcone and 3,4'-dihydroxychalcone at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria. 2) Chalcone and 4'-hydroxychalcone stimulate both latent and DNP-ATPase activity of mitochondria. Echinatin inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. 3) Chalcone and 4'-hydroxychalcone induce a rapid potassium release from mitochondrial vesicles, while Echinatin and 3,4'-dihydroxychalcone have lesser effect than the former two substances. From these results, it can be concluded that Echinatin and several related compounds disturb the mitochondrial energy transfer reactions and membrane permeability.

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.[Pubmed:23790887]

Food Chem. 2013 Nov 15;141(2):1063-71.

Licorice, the roots and rhizomes of several Glycyrrhiza species (Leguminosae), is an important natural sweetening agent and a widely used herbal medicine. In this work, six flavonoids, 5-(1,1-dimethylallyl)-3,4,4'-trihydroxy-2-methoxychalcone (1), licochalcone B (2), licochalcone A (3), Echinatin (4), glycycoumarin (5) and glyurallin B (6), were isolated from the extracts of licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Their structures were elucidated using various spectroscopic methods. To our knowledge, compound 1 was isolated from natural plants for the first time. All the isolates were tested by antioxidant and anti-inflammatory assays. Compounds 2, 4 and 5 showed strong scavenging activity toward the ABTS(+) radical, and compounds 1, 2, 3, 5 and 6 exhibited potent inhibition of lipid peroxidation in rat liver microsomes compared with the reference controls. Compounds 1-4 dose-dependently inhibited LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells. Furthermore, compounds 1-5 were demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Moreover, the contents of the six compounds, in different Glycyrrhiza species, were quantified by HPLC-MS.

Description

Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects. Echinatin may undergo an electron transfer (ET) and a proton transfer (PT) to cause the antioxidant action in aqueous solution. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat.

Keywords:

Echinatin,34221-41-5,4,4'-Dihydroxy 2-methoxychalcone; Retrochalcone,Natural Products, buy Echinatin , Echinatin supplier , purchase Echinatin , Echinatin cost , Echinatin manufacturer , order Echinatin , high purity Echinatin

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: