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Tovopyrifolin C

CAS# 34211-53-5

Tovopyrifolin C

Catalog No. BCN6888----Order now to get a substantial discount!

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Tovopyrifolin C: 5mg $725 In Stock
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Quality Control of Tovopyrifolin C

Number of papers citing our products

Chemical structure

Tovopyrifolin C

3D structure

Chemical Properties of Tovopyrifolin C

Cas No. 34211-53-5 SDF Download SDF
PubChem ID 5480342 Appearance Powder
Formula C14H10O6 M.Wt 274.23
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,3,5-trihydroxy-2-methoxyxanthen-9-one
SMILES COC1=C(C=C2C(=C1O)C(=O)C3=C(O2)C(=CC=C3)O)O
Standard InChIKey JAOZFCHZESUBKS-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H10O6/c1-19-14-8(16)5-9-10(12(14)18)11(17)6-3-2-4-7(15)13(6)20-9/h2-5,15-16,18H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tovopyrifolin C

The stem barks of Calophyllum venulosum.

Biological Activity of Tovopyrifolin C

DescriptionTovopyrifolin C is a natural product from Calophyllum venulosum.
In vitro

Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.[Pubmed: 23381024]

Molecules. 2013 Feb 4;18(2):1985-94.

The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied.
METHODS AND RESULTS:
Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), Tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines.
CONCLUSIONS:
The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.

Protocol of Tovopyrifolin C

Structure Identification
J Asian Nat Prod Res. 2015;17(11):1104-8.

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum.[Pubmed: 26023810]


METHODS AND RESULTS:
A new pyranoxanthone, venuloxanthone (1), was isolated from the stem bark of Calophyllum venulosum, together with three other xanthones, Tovopyrifolin C (2), ananixanthone (3) and caloxanthone I (4), along with two common triterpenes, friedelin (5) and lupeol (6).
CONCLUSIONS:
The structures of these compounds were identified using several spectroscopic analyses which are NMR, GCMS and FTIR experiments.

Tovopyrifolin C Dilution Calculator

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Tovopyrifolin C Molarity Calculator

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Preparing Stock Solutions of Tovopyrifolin C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6466 mL 18.2329 mL 36.4657 mL 72.9315 mL 91.1644 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL 14.5863 mL 18.2329 mL
10 mM 0.3647 mL 1.8233 mL 3.6466 mL 7.2931 mL 9.1164 mL
50 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.4586 mL 1.8233 mL
100 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.7293 mL 0.9116 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tovopyrifolin C

Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.[Pubmed:23381024]

Molecules. 2013 Feb 4;18(2):1985-94.

The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), Tovopyrifolin C (10) and alpha-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and alpha-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum.[Pubmed:26023810]

J Asian Nat Prod Res. 2015;17(11):1104-8.

A new pyranoxanthone, venuloxanthone (1), was isolated from the stem bark of Calophyllum venulosum, together with three other xanthones, Tovopyrifolin C (2), ananixanthone (3) and caloxanthone I (4), along with two common triterpenes, friedelin (5) and lupeol (6). The structures of these compounds were identified using several spectroscopic analyses which are NMR, GCMS and FTIR experiments.

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