Eupalinolide I

CAS# 1402067-84-8

Eupalinolide I

Catalog No. BCN7367----Order now to get a substantial discount!

Product Name & Size Price Stock
Eupalinolide I: 5mg $886 In Stock
Eupalinolide I: 10mg Please Inquire In Stock
Eupalinolide I: 20mg Please Inquire Please Inquire
Eupalinolide I: 50mg Please Inquire Please Inquire
Eupalinolide I: 100mg Please Inquire Please Inquire
Eupalinolide I: 200mg Please Inquire Please Inquire
Eupalinolide I: 500mg Please Inquire Please Inquire
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Chemical structure

Eupalinolide I

3D structure

Chemical Properties of Eupalinolide I

Cas No. 1402067-84-8 SDF Download SDF
PubChem ID 131847725 Appearance Oil
Formula C24H30O9 M.Wt 462.49
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(3aR,4R,6E,9R,10E,11aR)-9-acetyloxy-6-(acetyloxymethyl)-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate
SMILES CC1=CC2C(C(CC(=CCC1OC(=O)C)COC(=O)C)OC(=O)C(=CCO)C)C(=C)C(=O)O2
Standard InChIKey HPWMABTYJYZFLK-KPPLFFIBSA-N
Standard InChI InChI=1S/C24H30O9/c1-13(8-9-25)23(28)32-21-11-18(12-30-16(4)26)6-7-19(31-17(5)27)14(2)10-20-22(21)15(3)24(29)33-20/h6,8,10,19-22,25H,3,7,9,11-12H2,1-2,4-5H3/b13-8+,14-10+,18-6+/t19-,20-,21-,22+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Eupalinolide I

The aerial plants of Eupatorium lindleyanum.

Biological Activity of Eupalinolide I

TargetsSTAT

Eupalinolide I Dilution Calculator

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Eupalinolide I Molarity Calculator

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Preparing Stock Solutions of Eupalinolide I

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1622 mL 10.811 mL 21.6221 mL 43.2442 mL 54.0552 mL
5 mM 0.4324 mL 2.1622 mL 4.3244 mL 8.6488 mL 10.811 mL
10 mM 0.2162 mL 1.0811 mL 2.1622 mL 4.3244 mL 5.4055 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 0.8649 mL 1.0811 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.4324 mL 0.5406 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Eupalinolide I

Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed:29086600]

Nat Prod Res. 2017 Oct 31:1-9.

Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC). In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.

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