Fmoc-D-Tyr(tBu)-OH

CAS# 118488-18-9

Fmoc-D-Tyr(tBu)-OH

Catalog No. BCC3569----Order now to get a substantial discount!

Product Name & Size Price Stock
Fmoc-D-Tyr(tBu)-OH: 5mg $6 In Stock
Fmoc-D-Tyr(tBu)-OH: 10mg Please Inquire In Stock
Fmoc-D-Tyr(tBu)-OH: 20mg Please Inquire Please Inquire
Fmoc-D-Tyr(tBu)-OH: 50mg Please Inquire Please Inquire
Fmoc-D-Tyr(tBu)-OH: 100mg Please Inquire Please Inquire
Fmoc-D-Tyr(tBu)-OH: 200mg Please Inquire Please Inquire
Fmoc-D-Tyr(tBu)-OH: 500mg Please Inquire Please Inquire
Fmoc-D-Tyr(tBu)-OH: 1000mg Please Inquire Please Inquire
Related Products
  • PF-4708671

    Catalog No.:BCC5031
    CAS No.:1255517-76-0
  • BIX 02565

    Catalog No.:BCC4303
    CAS No.:1311367-27-7
  • BI-D1870

    Catalog No.:BCC5030
    CAS No.:501437-28-1
  • CMK

    Catalog No.:BCC1489
    CAS No.:821794-90-5

Quality Control of Fmoc-D-Tyr(tBu)-OH

Number of papers citing our products

Chemical structure

Fmoc-D-Tyr(tBu)-OH

3D structure

Chemical Properties of Fmoc-D-Tyr(tBu)-OH

Cas No. 118488-18-9 SDF Download SDF
PubChem ID 12968135 Appearance Powder
Formula C28H29NO5 M.Wt 459.5
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid
SMILES CC(C)(C)OC1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Standard InChIKey JAUKCFULLJFBFN-RUZDIDTESA-N
Standard InChI InChI=1S/C28H29NO5/c1-28(2,3)34-19-14-12-18(13-15-19)16-25(26(30)31)29-27(32)33-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,29,32)(H,30,31)/t25-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Fmoc-D-Tyr(tBu)-OH Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Fmoc-D-Tyr(tBu)-OH Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Fmoc-D-Tyr(tBu)-OH

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1763 mL 10.8814 mL 21.7628 mL 43.5256 mL 54.407 mL
5 mM 0.4353 mL 2.1763 mL 4.3526 mL 8.7051 mL 10.8814 mL
10 mM 0.2176 mL 1.0881 mL 2.1763 mL 4.3526 mL 5.4407 mL
50 mM 0.0435 mL 0.2176 mL 0.4353 mL 0.8705 mL 1.0881 mL
100 mM 0.0218 mL 0.1088 mL 0.2176 mL 0.4353 mL 0.5441 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Fmoc-D-Tyr(tBu)-OH

Fmoc-D-Tyr(tBu)-OH

Featured Products
New Products
 

References on Fmoc-D-Tyr(tBu)-OH

Radioimmunotherapy of MCF7 breast cancer cell line with 131I-PR81 monoclonal antibody against MUC1: comparison of direct and indirect radioiodination methods.[Pubmed:20555127]

Hum Antibodies. 2010;19(1):15-25.

PR81 is a monoclonal antibody that binds with high affinity to MUC1, which is over expressed on breast and other tumors. The objective of this study was to compare the two labeling methods (direct and indirect radioiodination) for application of this antibody against MUC1 as a radioimmunotherapeutical agent.Monoclonal antibody (PR81) against the tandem repeat of the core protein (MUC1) was prepared, characterized, purified, and labeled with 131I using the direct (chloramin-T) and indirect (Fmoc-D-Tyr (tBu)-D-Tyr (tBu)-D-Lys (Boc)-OH (YYK) attached to N-hydroxysuccinimide as a linker between PR81 and 131I) methods. The immunoreactivity of 131I-PR81 and 131I-TP-PR81 complexes with MUC1 (the native protein), BSA-P20 (a 20 amino acid corresponding the tandem repeat of MUC1) and MCF7 cell line were performed by RIA. In vitro stability of 131I-PR81 and 131I-YYK-peptide-PR81 complexes in human serum was determined by thin layer chromatography (TLC). Cell toxicity and in vitro internalization studies were performed with the MCF7 cell line, and the tissue biodistribution of the 131I-PR81 and 131I- YYK-peptide -PR81 complexes was evaluated in normal BALB/c mice at 4, 24 and 48 hrs. The labeling efficiency was determined by measuring the percentage recovery of radioactivity in the final product relative to the initial activity in the shipment vial, was found to be 59.9% +/- 7.9% for direct and 50% +/- 3.2% for indirect methods. 131I-PR81 and 131I- YYK- peptide -PR81 complexes showed high immunoreactivity towards MUC1 protein, BSA-P20 and MCF7 cell line. In vitro stability of the labeled products in human serum which was measured by thin layer chromatography (TLC) was found to be more than 50% over 24 hr for 131I-PR81 and 70% for 131I- YYK-peptide -PR81 complexes. Cell toxicity and in vitro internalization studies showed that the 131I-PR81 and 131I- YYK-peptide -PR81 complexes inhibited 80% growth of the MCF7 cultured cell lines in vitro in a high concentration and up to 40% of the 131I-PR81 and 60% of the 131I- YYK-peptide -PR81 complexes internalized after 24 h. Biodistribution studies were performed in normal BALB/c mice at 4, 24 and 48 hrs post-injection. Thyroid and stomach levels from PR81 labeled with 131I- YYK-peptide were two- to three- fold less than those with directly labeled 131I-PR81, suggesting low recognition of its D-iodotyrosine residue by endogenous deiodinase. These results show that the indirect labeling was better than the indirect labeling and 131I- YYK-peptide -PR81 may be considered as a promising candidate for therapy of breast cancer.

Keywords:

Fmoc-D-Tyr(tBu)-OH,118488-18-9,Natural Products,Fmoc-Amino Acids and Derivatives, buy Fmoc-D-Tyr(tBu)-OH , Fmoc-D-Tyr(tBu)-OH supplier , purchase Fmoc-D-Tyr(tBu)-OH , Fmoc-D-Tyr(tBu)-OH cost , Fmoc-D-Tyr(tBu)-OH manufacturer , order Fmoc-D-Tyr(tBu)-OH , high purity Fmoc-D-Tyr(tBu)-OH

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: