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UNC 926 hydrochloride

Inhibitor of methyl lysine reader domain CAS# 1184136-10-4

UNC 926 hydrochloride

Catalog No. BCC2445----Order now to get a substantial discount!

Product Name & Size Price Stock
UNC 926 hydrochloride: 5mg $104 In Stock
UNC 926 hydrochloride: 10mg Please Inquire In Stock
UNC 926 hydrochloride: 20mg Please Inquire Please Inquire
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Quality Control of UNC 926 hydrochloride

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Chemical structure

UNC 926 hydrochloride

3D structure

Chemical Properties of UNC 926 hydrochloride

Cas No. 1184136-10-4 SDF Download SDF
PubChem ID 61041645 Appearance Powder
Formula C16H21BrN2O M.Wt 337.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 155 mg/mL (459.60 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
SMILES C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CC=C3)Br
Standard InChIKey OWGLFIKZKQOYHZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H21BrN2O/c17-14-5-3-4-13(12-14)16(20)19-10-6-15(7-11-19)18-8-1-2-9-18/h3-5,12,15H,1-2,6-11H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of UNC 926 hydrochloride

DescriptionMethyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.

UNC 926 hydrochloride Dilution Calculator

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UNC 926 hydrochloride Molarity Calculator

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Preparing Stock Solutions of UNC 926 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9647 mL 14.8236 mL 29.6472 mL 59.2944 mL 74.118 mL
5 mM 0.5929 mL 2.9647 mL 5.9294 mL 11.8589 mL 14.8236 mL
10 mM 0.2965 mL 1.4824 mL 2.9647 mL 5.9294 mL 7.4118 mL
50 mM 0.0593 mL 0.2965 mL 0.5929 mL 1.1859 mL 1.4824 mL
100 mM 0.0296 mL 0.1482 mL 0.2965 mL 0.5929 mL 0.7412 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on UNC 926 hydrochloride

Methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits, in a dose-dependent manner, the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull down assay.

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Description

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.

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