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Ganoderenic acid E

CAS# 110241-23-1

Ganoderenic acid E

Catalog No. BCN8241----Order now to get a substantial discount!

Product Name & Size Price Stock
Ganoderenic acid E: 5mg $322 In Stock
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Quality Control of Ganoderenic acid E

Number of papers citing our products

Chemical structure

Ganoderenic acid E

3D structure

Chemical Properties of Ganoderenic acid E

Cas No. 110241-23-1 SDF Download SDF
PubChem ID 131801361 Appearance Powder
Formula C30H40O8 M.Wt 528.63
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E,2S)-6-[(7S,10S,12S,13R,14R)-7,12-dihydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-1,2,5,6,7,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxohept-5-enoic acid
SMILES CC(CC(=O)C=C(C)C1CC(=O)C2(C1(C(C(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)O)C)C)C(=O)O
Standard InChIKey UFIFFDILGAASQL-XYZDLWCTSA-N
Standard InChI InChI=1S/C30H40O8/c1-14(10-16(31)11-15(2)26(37)38)17-12-21(34)30(7)22-18(32)13-19-27(3,4)20(33)8-9-28(19,5)23(22)24(35)25(36)29(17,30)6/h10,15,17-19,25,32,36H,8-9,11-13H2,1-7H3,(H,37,38)/b14-10+/t15-,17?,18-,19?,25+,28-,29-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ganoderenic acid E

The fruit body of Ganoderma lucidum

Biological Activity of Ganoderenic acid E

In vitro

Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice.[Reference: WebLink]

Journal of ethnopharmacology, 2017, 210:287.

Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective components of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma sinense Zhao, Xu et Zhang, which have been used for adjuvant anti-cancer clinical therapy for more than 20 years. However, its concrete active components and its regulation mechanisms on tumor are unclear. In this study, we aimed to identify the main active compounds from GLE and to investigate its anti-cancer mechanisms via drug-target biological network construction and prediction.
METHODS AND RESULTS:
The main active compounds of GLE were identified by HPLC, EI-MS and NMR, and the compounds related targets were predicted using docking program. To investigate the functions of GL holistically, the whole active components of GL and related targets were predicted based on four public databases. Subsequently, the compound-target network and component-target network were constructed respectively, and they were overlapped to detect the kernel potential targets in both networks. Furthermore, the qRT-PCR was used to validate the expression levels of target genes in GLE treated Hepa1-6-bearing C57 BL/6 mice. In our work, 12 active compounds of GLE were identified, including Ganoderic acid A, Ganoderenic acid A, Ganoderic acid B, Ganoderic acid H, Ganoderic acid C2, ganoderenic acid D, Ganoderic acid D, Ganoderenic acid G, Ganoderic acid Y, Kaemferol, Genistein and Ergosterol. Using the docking program, 20 targets were mapped to 12 compounds of GLE. Furthermore, 122 effective active components of GL and 116 targets were holistically predicted using public databases. Compare with the compound-target network and component-target network, 6 kernel targets were screened, including AR, CHRM2, ESR1, NR3C1, NR3C2 and PGR, which was considered as potential markers and might play important roles in the process of GLE treatment. GLE effectively inhibited tumor growth in Hepa1-6-bearing C57 BL/6 mice. Moreover, qRT-PCR data demonstrated the expression levels of NR3C1, NR3C2 and AR are up-regulated and PGR, ESR1 and CHRM2 are down-regulated.
CONCLUSIONS:
The results indicated that these 6 kernel target genes might act as potential markers to evaluate the curative effect of GLE treatment in tumor. The combined data provide preliminary study of the pharmacological mechanisms of GLE. GLE may be a promising potential therapeutic and chemopreventative candidate for anti-cancer.

Ganoderenic acid E Dilution Calculator

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Preparing Stock Solutions of Ganoderenic acid E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8917 mL 9.4584 mL 18.9168 mL 37.8336 mL 47.2921 mL
5 mM 0.3783 mL 1.8917 mL 3.7834 mL 7.5667 mL 9.4584 mL
10 mM 0.1892 mL 0.9458 mL 1.8917 mL 3.7834 mL 4.7292 mL
50 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.7567 mL 0.9458 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.3783 mL 0.4729 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

Ganoderenic acid E is a lanostane-type triterpene isolated from Ganoderma lucidum.

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