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7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

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7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

Catalog No. BCC3319----Order now to get a substantial discount!

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7'(Z)-(8''R,8'''R)-epi-salvianolic acid E : 5mg Please Inquire In Stock
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7'(Z)-(8''R,8'''R)-epi-salvianolic acid E : 1000mg Please Inquire Please Inquire
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Quality Control of 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

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Chemical structure

7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

3D structure

Chemical Properties of 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

Cas No. N/A SDF Download SDF
PubChem ID 127041552 Appearance Powder
Formula C36H30O16 M.Wt 718.6
Type of Compound Lignans Storage Desiccate at -20°C
Synonyms (7'Z,8''S,8'''S)-Episalvianolic acid E
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-2-[(E)-3-[2-[(Z)-3-[(1S)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-1-(3,4-dihydroxyphenyl)-3-oxoprop-1-en-2-yl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
SMILES C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C(C(=C(C=C2)O)O)C(=CC3=CC(=C(C=C3)O)O)C(=O)OC(CC4=CC(=C(C=C4)O)O)C(=O)O)O)O
Standard InChIKey SOXUSBQFIOBYJU-SSGHVCSZSA-N
Standard InChI InChI=1S/C36H30O16/c37-22-6-1-17(12-26(22)41)11-21(36(50)52-30(35(48)49)16-19-3-8-24(39)28(43)14-19)32-20(4-9-25(40)33(32)45)5-10-31(44)51-29(34(46)47)15-18-2-7-23(38)27(42)13-18/h1-14,29-30,37-43,45H,15-16H2,(H,46,47)(H,48,49)/b10-5+,21-11-/t29-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

The root of Salvia miltiorrhiza Bge.

Biological Activity of 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

In vitro

Development and validation of a UFLC-MS/MS method for determination of 7'(Z)-(8″S, 8‴S)-epi-salvianolic acid E, (7'R, 8'R, 8″S, 8‴S)-epi-salvianolic acid B and salvianolic acid B in rat plasma and its application to pharmacokinetic studies.[Pubmed: 27064533]

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:6-12.

7'(Z)-(8″S, 8‴S)-epi-Salvianolic acid E (compound 1) and (7'R, 8'R, 8″S, 8‴S)-epi-salvianolic acid B (compound 2), two novel analogs of salvianolic acid B (Sal B), have been recently isolated from Salvianolic acid for injection. They both show powerful antioxidant effects, including inducing NQO1 activity and scavenging DPPH free radical, and potential protecting effects for cerebral ischemia. However, no reports have been described the pharmacokinetic study of them.
METHODS AND RESULTS:
In this study, an ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed and validated for the determination of compound 1, compound 2 and Sal B in rat plasma, respectively. Plasma samples were pretreated by liquid-liquid extraction with ethyl acetate. Chromatographic separation was achieved on a Waters Acquity UPLC(®) HSS T3 column (1.7μm particles, 2.1mm i.d.×100mm) with the mobile phase of 0.1% aqueous formic acid (A)-acetonitrile (B) (65:35, v/v). Quantification was performed on a triple quadruple tandem mass spectrometry with electrospray ionization (ESI) by multiple reaction monitoring (MRM) in the negative ion mode. Monitored transitions were set at m/z 717.0→519.0, 717.1→519.1, 717.2→518.9 and 320.9→152.1 for compound 1, compound 2, Sal B and chloramphenicol (internal standard, IS), respectively. Linear calibration curves were acquired over the concentration range of 2.0-1000ng/mL for the three analytes in rat plasma. The extraction recoveries, matrix effects, intra- and inter-day precisions and accuracies of the three analytes were all within acceptable limits. The validated method was successfully applied to the pharmacokinetic study of compound 1, compound 2 and Sal B after intravenous administration of 6.0mg/kg in rats, respectively.
CONCLUSIONS:
The results indicated that compound 1 and compound 2 were both eliminated more slowly than Sal B. Exposure levels of both compound 1 and Sal B were higher than compound 2 in the same dosage range. This study provided critical reference for the pharmacokinetic study of compound 1 and compound 2.

7'(Z)-(8''R,8'''R)-epi-salvianolic acid E Dilution Calculator

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7'(Z)-(8''R,8'''R)-epi-salvianolic acid E Molarity Calculator

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Preparing Stock Solutions of 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3916 mL 6.958 mL 13.9159 mL 27.8319 mL 34.7899 mL
5 mM 0.2783 mL 1.3916 mL 2.7832 mL 5.5664 mL 6.958 mL
10 mM 0.1392 mL 0.6958 mL 1.3916 mL 2.7832 mL 3.479 mL
50 mM 0.0278 mL 0.1392 mL 0.2783 mL 0.5566 mL 0.6958 mL
100 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.2783 mL 0.3479 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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