JX 401

CAS# 349087-34-9

JX 401

Catalog No. BCC7443----Order now to get a substantial discount!

Product Name & Size Price Stock
JX 401: 5mg $115 In Stock
JX 401: 10mg Please Inquire In Stock
JX 401: 20mg Please Inquire Please Inquire
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Quality Control of JX 401

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Chemical structure

JX 401

3D structure

Chemical Properties of JX 401

Cas No. 349087-34-9 SDF Download SDF
PubChem ID 1126109 Appearance Powder
Formula C21H25NO2S M.Wt 355.49
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 75 mM in DMSO and to 50 mM in ethanol
Chemical Name (4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
SMILES COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3
Standard InChIKey OMGLGPKQUFSRNN-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of JX 401

DescriptionPotent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

JX 401 Dilution Calculator

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JX 401 Molarity Calculator

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Preparing Stock Solutions of JX 401

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.813 mL 14.0651 mL 28.1302 mL 56.2604 mL 70.3255 mL
5 mM 0.5626 mL 2.813 mL 5.626 mL 11.2521 mL 14.0651 mL
10 mM 0.2813 mL 1.4065 mL 2.813 mL 5.626 mL 7.0325 mL
50 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.1252 mL 1.4065 mL
100 mM 0.0281 mL 0.1407 mL 0.2813 mL 0.5626 mL 0.7033 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on JX 401

JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.[Pubmed:16847144]

Mol Pharmacol. 2006 Oct;70(4):1395-405.

In vivo screening of compounds for potential pharmacological activity is more advantageous than in vitro screening. In vivo screens eliminate the isolation of compounds that cannot cross biological membranes, are cytotoxic, or are not specific to the target. However, animal-based or even cell-based systems are usually expensive, time-consuming, and laborious. Here we describe the identification of inhibitors of the mitogen-activated protein kinase p38alpha via a high throughput screen using yeast cells. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. However, there are currently no p38alpha inhibitors in clinical use. Because the human p38alpha imposes severe growth retardation when expressed in yeast, we screened a library of 40,000 randomly selected small molecules for compounds that would restore a normal growth rate. We identified two compounds; both share a structural motif of 4-benzylpiperidine, and both were shown to be efficient and selective p38alpha inhibitors in vitro. They were also active in mammalian cells, as manifested by their ability to reversibly inhibit myoblast differentiation. Thus, the yeast screen identified efficient and specific p38alpha inhibitors that are capable of crossing biological membranes, are not toxic, and function in mammalian cells. The rapid and cost-efficient high-throughput screening used here could be applied for isolation of inhibitors of various targets.

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