Kansuinine B

CAS# 57685-46-8

Kansuinine B

Catalog No. BCN3766----Order now to get a substantial discount!

Product Name & Size Price Stock
Kansuinine B: 5mg Please Inquire In Stock
Kansuinine B: 10mg Please Inquire In Stock
Kansuinine B: 20mg Please Inquire Please Inquire
Kansuinine B: 50mg Please Inquire Please Inquire
Kansuinine B: 100mg Please Inquire Please Inquire
Kansuinine B: 200mg Please Inquire Please Inquire
Kansuinine B: 500mg Please Inquire Please Inquire
Kansuinine B: 1000mg Please Inquire Please Inquire

Quality Control of Kansuinine B

Number of papers citing our products

Chemical structure

Kansuinine B

3D structure

Chemical Properties of Kansuinine B

Cas No. 57685-46-8 SDF Download SDF
PubChem ID 442050 Appearance Powder
Formula C38H42O14 M.Wt 722.7
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1C2C(O2)C(C(=O)C(C(C(=C)C(C3C(C(C(C3(C1=O)OC(=O)C)O)(C)O)OC(=O)C)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5)O)(C)C
Standard InChIKey JFOILMZFESGPDU-GXRLDEOZSA-N
Standard InChI InChI=1S/C38H42O14/c1-18-26(50-33(44)22-14-10-8-11-15-22)24-31(48-20(3)39)37(7,47)35(46)38(24,52-21(4)40)29(42)19(2)28-32(49-28)36(5,6)30(43)25(41)27(18)51-34(45)23-16-12-9-13-17-23/h8-17,19,24-28,31-32,35,41,46-47H,1H2,2-7H3/t19-,24-,25+,26-,27-,28-,31+,32+,35-,37-,38+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kansuinine B

The roots of Euphorbia kansui

Biological Activity of Kansuinine B

Description1. Kansuinine B shows cytotoxic activity. 2. Kansuinine B shows analgesic activity. 3. Treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects.
TargetsIL Receptor | STAT | ERK | MEK

Kansuinine B Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Kansuinine B Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Kansuinine B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3837 mL 6.9185 mL 13.837 mL 27.674 mL 34.5925 mL
5 mM 0.2767 mL 1.3837 mL 2.7674 mL 5.5348 mL 6.9185 mL
10 mM 0.1384 mL 0.6919 mL 1.3837 mL 2.7674 mL 3.4593 mL
50 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.5535 mL 0.6919 mL
100 mM 0.0138 mL 0.0692 mL 0.1384 mL 0.2767 mL 0.3459 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Kansuinine B

Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation.[Pubmed:20379953]

Planta Med. 2010 Oct;76(14):1544-9.

The current study was performed to examine the mechanisms underlying the potential effects of E. KANSUI on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

Keywords:

Kansuinine B,57685-46-8,Natural Products, buy Kansuinine B , Kansuinine B supplier , purchase Kansuinine B , Kansuinine B cost , Kansuinine B manufacturer , order Kansuinine B , high purity Kansuinine B

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: