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WAY 629 hydrochloride

Selective 5-HT2C agonist CAS# 57756-44-2

WAY 629 hydrochloride

Catalog No. BCC7271----Order now to get a substantial discount!

Product Name & Size Price Stock
WAY 629 hydrochloride: 5mg $81 In Stock
WAY 629 hydrochloride: 10mg Please Inquire In Stock
WAY 629 hydrochloride: 20mg Please Inquire Please Inquire
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Quality Control of WAY 629 hydrochloride

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Chemical structure

WAY 629 hydrochloride

3D structure

Chemical Properties of WAY 629 hydrochloride

Cas No. 57756-44-2 SDF Download SDF
PubChem ID 12259556 Appearance Powder
Formula C15H19ClN2 M.Wt 262.78
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
SMILES C1CCC2=C(C1)C3=C4N2CCNCC4=CC=C3.Cl
Standard InChIKey PZXUJERSOFOWES-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H18N2.ClH/c1-2-7-14-12(5-1)13-6-3-4-11-10-16-8-9-17(14)15(11)13;/h3-4,6,16H,1-2,5,7-10H2;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of WAY 629 hydrochloride

DescriptionSelective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.

WAY 629 hydrochloride Dilution Calculator

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WAY 629 hydrochloride Molarity Calculator

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Preparing Stock Solutions of WAY 629 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8055 mL 19.0273 mL 38.0546 mL 76.1093 mL 95.1366 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL 15.2219 mL 19.0273 mL
10 mM 0.3805 mL 1.9027 mL 3.8055 mL 7.6109 mL 9.5137 mL
50 mM 0.0761 mL 0.3805 mL 0.7611 mL 1.5222 mL 1.9027 mL
100 mM 0.0381 mL 0.1903 mL 0.3805 mL 0.7611 mL 0.9514 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on WAY 629 hydrochloride

Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.[Pubmed:15109661]

Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7.

Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT(2C) receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K(i) 56 nM, E(max) 90%), which is selective for the 5-HT(2C) receptor versus other serotonin receptor subtypes, and dopamine, histamine, adrenergic, and muscarinic receptors. In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K(i) 13 nM, E(max) 102%).

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