Limonol

CAS# 989-61-7

Limonol

Catalog No. BCN4533----Order now to get a substantial discount!

Product Name & Size Price Stock
Limonol: 5mg $886 In Stock
Limonol: 10mg Please Inquire In Stock
Limonol: 20mg Please Inquire Please Inquire
Limonol: 50mg Please Inquire Please Inquire
Limonol: 100mg Please Inquire Please Inquire
Limonol: 200mg Please Inquire Please Inquire
Limonol: 500mg Please Inquire Please Inquire
Limonol: 1000mg Please Inquire Please Inquire

Quality Control of Limonol

Number of papers citing our products

Chemical structure

Limonol

3D structure

Chemical Properties of Limonol

Cas No. 989-61-7 SDF Download SDF
PubChem ID 3083667 Appearance Powder
Formula C26H32O8 M.Wt 472.5
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C2CC(C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)O)C
Standard InChIKey ZFIURKZEANVFML-GJXGUZPUSA-N
Standard InChI InChI=1S/C26H32O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-17,19-20,27H,5,7,9-10,12H2,1-4H3/t14?,15?,16?,17?,19-,20?,23-,24?,25?,26?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Limonol

The barks of Melia azedarach L.

Biological Activity of Limonol

Description1. Limonol-derivatives could as promising scaffolds for the design of novel Hsp90α inhibitors.
TargetsRaf | ATPase | Akt | HSP (e.g. HSP90)

Limonol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Limonol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Limonol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1164 mL 10.582 mL 21.164 mL 42.328 mL 52.9101 mL
5 mM 0.4233 mL 2.1164 mL 4.2328 mL 8.4656 mL 10.582 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL 4.2328 mL 5.291 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 0.8466 mL 1.0582 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4233 mL 0.5291 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Limonol

Antifungal activity of some tetranortriterpenoids.[Pubmed:10844171]

Fitoterapia. 2000 Jun;71(3):317-20.

Natural tetranortriterpenoids such as cedrelone from Toona ciliata, azadiradione from Azadirachta indica, limonin, Limonol and nomilinic acid from Citrus medica, along with some cedrelone derivatives were tested for their antifungal activity against Puccinia arachidis, a groundnut rust pathogen. Results show that cedrelone was the most effective in reducing rust pustule emergence. Replacement of functional groups or modification of the A or the B ring in cedrelone reduced the effectiveness indicating the importance of specific structural features for activity.

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.[Pubmed:27492719]

Chemistry. 2016 Sep 5;22(37):13236-50.

The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies. In an attempt to identify new small molecules modulating the activity of Hsp90, we screened a small library of tetranortriterpenes. A high-affinity interaction with Hsp90 inducible form was uncovered for eight of these compounds, five of which are described here for the first time. By monitoring the ATPase activity and the citrate synthase thermal induced aggregation, compound 1 (cedrelosin A), 3 (7alpha-limonylacetate), and 5 (cedrelosin B), containing a Limonol moiety, were found to be the most effective in compromising the Hsp90alpha chaperone activity. Consistent with these findings, the three compounds caused a depletion of c-Raf and pAkt Hsp90 client proteins in HeLa and MCF/7 cell lines. Induced fit docking protocol and molecular dynamics were used to rationalize the structural basis of the biological activity of the Limonol derivatives. Taken together, these results point to Limonol-derivatives as promising scaffolds for the design of novel Hsp90alpha inhibitors.

Keywords:

Limonol,989-61-7,Natural Products, buy Limonol , Limonol supplier , purchase Limonol , Limonol cost , Limonol manufacturer , order Limonol , high purity Limonol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: