Magnoloside A

CAS# 113557-95-2

Magnoloside A

Catalog No. BCN6013----Order now to get a substantial discount!

Product Name & Size Price Stock
Magnoloside A: 5mg $265 In Stock
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Quality Control of Magnoloside A

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Chemical structure

Magnoloside A

3D structure

Chemical Properties of Magnoloside A

Cas No. 113557-95-2 SDF Download SDF
PubChem ID 21629882 Appearance Powder
Formula C29H36O15 M.Wt 624.6
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2R,3R,4R,5R,6R)-2-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-4-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OCCC3=CC(=C(C=C3)O)O)CO)O)OC(=O)C=CC4=CC(=C(C=C4)O)O)O)O)O
Standard InChIKey QLZWUGOYBODRLF-QQLYGORSSA-N
Standard InChI InChI=1S/C29H36O15/c1-13-22(36)24(38)25(39)28(41-13)44-27-26(43-21(35)7-4-14-2-5-16(31)18(33)10-14)23(37)20(12-30)42-29(27)40-9-8-15-3-6-17(32)19(34)11-15/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28-,29+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Magnoloside A

The bark of Magnolia obovata

Biological Activity of Magnoloside A

DescriptionMagnoloside A has potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 ug/ml.
TargetsAntifection
In vitro

A Phenylpropanoid Glycoside as a Calcineurin Inhibitor Isolated from Magnolia obovata Thunb.[Pubmed: 26174771 ]

J Microbiol Biotechnol. 2015 Sep;25(9):1429-32.


METHODS AND RESULTS:
To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans.
CONCLUSIONS:
This compound was identified as Magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

Protocol of Magnoloside A

Structure Identification
J Chromatogr Sci. 2015 Apr;53(4):598-602.

An HPLC-DAD Method for Simultaneous Quantitative Determination of Four Active Hydrophilic Compounds in Magnoliae Officinalis Cortex.[Pubmed: 25085894]

Magnoliae officinalis cortex (MOC), derived from Magnolia officinalis and its variation M. officinalis var. biloba, is an important traditional Chinese medicine.
METHODS AND RESULTS:
In our previous work, 11 hydrophilic ingredients of MOC were isolated and structurally elucidated and four, namely syringin (SG), Magnoloside A (MA), magnoloside B (MB) and magnoflorine (MF), showed bioactive effects. Herein, we describe an HPLC-DAD method for the simultaneous quantitative determination of MA, MB, MF and SG in MOC for the first time. The chromatographic separation of samples was performed on an Agilent Zorbax SB-C18 column (250 × 4.6 mm i.d., 5 µm) by gradient elution with water-acetic acid (pH 3.0) and methanol at a flow rate of 1.0 mL/min. The wavelengths were set at 265 nm for MF and SG, and 328 nm for MA and MB. The average recovery of the four compounds was from 97.63 to 103.84%. Nearly 100 MOC samples harvested from eight habitats were analyzed in which the contents of the tested compound varied in the range of 0.016-0.350% (MF), 0.010-0.337% (SG), 0.017-3.009% (MB) and 0.077-2.529% (MA).
CONCLUSIONS:
The analysis also indicated that MOC contains a significant amount of phenylethanoid glycosides. This was an unexpected finding because previously lignan was considered to be the main component of MOC.

Magnoloside A Dilution Calculator

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Magnoloside A Molarity Calculator

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Preparing Stock Solutions of Magnoloside A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.601 mL 8.0051 mL 16.0102 mL 32.0205 mL 40.0256 mL
5 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
10 mM 0.1601 mL 0.8005 mL 1.601 mL 3.202 mL 4.0026 mL
50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Magnoloside A

An HPLC-DAD method for simultaneous quantitative determination of four active hydrophilic compounds in Magnoliae officinalis cortex.[Pubmed:25085894]

J Chromatogr Sci. 2015 Apr;53(4):598-602.

Magnoliae officinalis cortex (MOC), derived from Magnolia officinalis and its variation M. officinalis var. biloba, is an important traditional Chinese medicine. In our previous work, 11 hydrophilic ingredients of MOC were isolated and structurally elucidated and four, namely syringin (SG), Magnoloside A (MA), magnoloside B (MB) and magnoflorine (MF), showed bioactive effects. Herein, we describe an HPLC-DAD method for the simultaneous quantitative determination of MA, MB, MF and SG in MOC for the first time. The chromatographic separation of samples was performed on an Agilent Zorbax SB-C18 column (250 x 4.6 mm i.d., 5 microm) by gradient elution with water-acetic acid (pH 3.0) and methanol at a flow rate of 1.0 mL/min. The wavelengths were set at 265 nm for MF and SG, and 328 nm for MA and MB. The average recovery of the four compounds was from 97.63 to 103.84%. Nearly 100 MOC samples harvested from eight habitats were analyzed in which the contents of the tested compound varied in the range of 0.016-0.350% (MF), 0.010-0.337% (SG), 0.017-3.009% (MB) and 0.077-2.529% (MA). The analysis also indicated that MOC contains a significant amount of phenylethanoid glycosides. This was an unexpected finding because previously lignan was considered to be the main component of MOC.

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