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Mitotane (Lsodren)

Antineoplastic agents against adrenocortical carcinoma CAS# 53-19-0

Mitotane (Lsodren)

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Chemical structure

Mitotane (Lsodren)

3D structure

Chemical Properties of Mitotane (Lsodren)

Cas No. 53-19-0 SDF Download SDF
PubChem ID 4211 Appearance Powder
Formula C14H10Cl4 M.Wt 320.04
Type of Compound N/A Storage Desiccate at -20°C
Synonyms 2,4′-DDD; o,p'-DDD
Solubility DMSO : ≥ 100 mg/mL (312.46 mM)
H2O : < 0.1 mg/mL (insoluble)
*"≥" means soluble, but saturation unknown.
Chemical Name 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Standard InChIKey JWBOIMRXGHLCPP-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Mitotane (Lsodren)

DescriptionMitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. IC50 value: Target: Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%).

References:
[1]. Gentilin E, Tagliati F, Terzolo M, Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function. J Endocrinol. 2013 Jul 29;218(3):275-285. [2]. Lehmann TP, Wrzesiński T, Jagodziński PP. The effect of mitotane on viability, steroidogenesis and gene expression in NCI H295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900. [3]. Takeshita A, Igarashi-Migitaka J, Koibuchi N, Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor. J Endocrinol. 2013 Feb 15;216(3):297-305. [4]. Ederhy S, Cohen A, Dufaitre G, No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocortical carcinoma. J Endocrinol Invest. 2012 Nov;35(10):911-4. [5]. Alexandraki KI, Kaltsas GA, le Roux CW, Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study. Clin Endocrinol (Oxf). 2010 Mar;72(3):305-11.

Mitotane (Lsodren) Dilution Calculator

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Mitotane (Lsodren) Molarity Calculator

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Preparing Stock Solutions of Mitotane (Lsodren)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1246 mL 15.623 mL 31.2461 mL 62.4922 mL 78.1152 mL
5 mM 0.6249 mL 3.1246 mL 6.2492 mL 12.4984 mL 15.623 mL
10 mM 0.3125 mL 1.5623 mL 3.1246 mL 6.2492 mL 7.8115 mL
50 mM 0.0625 mL 0.3125 mL 0.6249 mL 1.2498 mL 1.5623 mL
100 mM 0.0312 mL 0.1562 mL 0.3125 mL 0.6249 mL 0.7812 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Mitotane (Lsodren)

Mitotane, or o,p'-DDD, is a derivative of DDT with antiproliferative properties. A study of the antiproliferative effects of Mitotane demonstrated particular efficacy against adrenocortical carcinoma.

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Description

Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.

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